2-Deoxy-D-glucose IV with DCA, Ketogenic Diet

Achieving Ketosis is a dietary therapy option for cancer patients, lowering the possibility of feeding the cancer growth with glucose. Ketogenic diets are also used for a variety of neurological disease states such as Alzheimers, epilepsy and parkinsons disease and other neurodegenerative disorders.

Ketones are a special type of fat that can stimulate the pathways that enhance the growth of new neural networks in the brain. A ketogenic diet is one that is high in fats, and this diet has been a tool of researchers for years, used notably in a 2005 study on Parkinson’s patients finding significant improvements. Ketones do more than just that though. They increase glutathione, a powerful, brain-protective antioxidant. Ketones facilitate the production of mitochondria, one of the most important actors in the coordinated production that is the human body. 

Our bodies are said to enter ketosis at the point when blood sugar levels are low and liver glycogen are no longer available to produce glucose as a fuel for cellular energy production. At this point, not only is the body doing the natural thing, and burning off fat, it’s also powering up the brain with a super efficient fuel.    We can jump start ourselves into ketosis with a brief fast, allowing our body to quickly burn through the carbs that are in our system, and turn to fat for fuel. A ketogenic diet is one that derives around 80% or more of of its calories from fat, and the rest from carbs and proteins.


2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis). In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with exception of liver and kidney); thus, labelled forms of 2-deoxyglucose serve as a good marker for tissue glucose uptake and hexokinase activity.

Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where distribution is assessed by tissue-slicing followed by autoradiography, sometimes in tandem with either conventional or electron microscopy. Clinicians have noted that 2-DG is metabolised in the pentose phosphate pathway in red blood cells at least, although the significance of this for other cell types and for cancer treatment in general is unclear.



DCA Dosage & the
DCA-Tea-B1 Protocol

It appears that DCA works vastly better when used in combination with caffeinated tea and vitamin B1. Reports and an early survey indicate that caffeinated tea is critical. Vitamin B1 may be essential as well. We recommend using all three: DCA, black tea and vitamin B1.

If this DCA-Tea-B1 synergy proves effective against most cancers, then the dose can probably stay low, making side effect issues much less of a concern.
 

  1.  It is clear from the research that one must be very careful about not going too high with the dosage of DCA for too long a period. Adults may have problems using dosages at 25 mg/kg of body weight and above for protracted periods. We see people showing side effects even at 14 to 15 mg/kg of body weight per day after three to six weeks.
     
  2. The Michelakis paper states that DCA is dose-dependent, meaning the higher the dose of DCA the better the response. The Michelakis patent gives a dose range of 10 mg/kg of body weight to 100 mg/kg for tumor action. 

The half-life of DCA in the body is about 24 hours, so drug holidays are a good way to lower the levels of DCA and avoid side effects. In using DCA, we urge you to consider the full protocol of DCA, caffeinated tea and vitamin B1. It appears that you can use lower doses of DCA in this protocol. Side effects are still a concern, so adjust accordingly if side effects appear.



How Often Should
DCA be Taken?

Our recommendation is once or twice a day. Split the dosage and take half in the morning and half at night. We have seen a number of excellent responses with once a day treatments. 

Side effects from DCA are reported even with doses of 13 to 14 mg/kg after 6 to 8 weeks. Considering the half-life of DCA (the amount of time necessary to metabolize and eliminate half of the DCA in one’s system) can run as long as 24 hours, getting off DCA periodically might help keep the levels low and make managing side effects much easier. Good suggestions we hear include taking DCA every other day, or taking DCA Monday through Friday and not taking it on weekends.

Metabolic theory of cancer & supportive therapies including DCA and 2-Deoxy-D-glucose offered at Dr C Golding medical practice

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Cancer Treatment using Hyperthermia!

Cancer Treatment using Hyperthermia!


What is hyperthermia?

Hyperthermia (also called thermal therapy or thermotherapy) is a type of cancer treatment in which body tissue is exposed to high temperatures (up to 41 degrees celsius). Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. By killing cancer cells and damaging proteins and structures within cells, hyperthermia may shrink tumors.

Hyperthermia is almost always used with other forms of cancer therapy.

  • In local hyperthermia, heat is applied to a small area, such as a tumor, using various techniques that deliver energy to heat the tumor. Different types of energy may be used to apply heat, including microwave, radiofrequency, and ultrasound. Depending on the tumor location, there are several approaches to local hyperthermia:
  • In regional hyperthermia, various approaches may be used to heat large areas of tissue, such as a body cavity, organ, or limb.
  • Whole-body hyperthermia is used to treat metastatic cancer that has spread throughout the body. This can be accomplished by several techniques that raise the body temperature to 107–108°F, including the use of thermal chambers (similar to large incubators) or hot water blankets.

The effectiveness of hyperthermia treatment is related to the temperature achieved during the treatment, as well as the length of treatment and cell and tissue characteristics. To ensure that the desired temperature is reached, but not exceeded, the temperature of the tumor and surrounding tissue is monitored throughout hyperthermia treatment.


The Cocoon Wellness Pro is a personalized sauna, detox, and weight loss system designed for full body comfort and relaxation. The Cocoon POD includes both infrared (IR) and traditional dry (sauna) heat features


Unique to the sauna industry, SaunaWellness Sauna  IR-PRO includes tri-spectrum infrared (IR) heating. This unique system allows the you to experience the benefits of three separate wavelengths for fast and even heating.

FAR Infrared Sauna

Our bodies have many ways of ridding itself from toxins and free radicals that build up.  One of these ways is through natural sweating. A FAR infrared sauna penetrates the body and raises the body’s core temperature, which in turn promotes more sweat to be formed.  Because of the penetration of the infrared technology, the sweat contains more toxins than one would sweat out in a traditional hot rock or wet sauna. 

What can I expect from a FAR infrared sauna session and what will it do for me?

  • Patients who go for Far infrared sauna sessions often experience deep relaxation during and after a treatment
  • FAR infrared sauna is an excellent addition to most treatments

Patients often report better sleeping patterns after sessions

Who can get FAR infrared sauna sessions?

FAR infrared sauna is available to anybody except pregnant women and children under five. Always check with your healthcare provider before starting FAR infrared sauna therapy.

How long does it take?

A standard session of far infrared sauna takes between 35 and 45 minutes.


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Contact Dr Craige Golding

Selected References

  1. van der Zee J. Heating the patient: A promising approach? Annals of Oncology 2002; 13:1173–1184.
  2. Hildebrandt B, Wust P, Ahlers O, et al. The cellular and molecular basis of hyperthermia. Critical Reviews in Oncology/Hematology 2002; 43:33–56.
  3. Wust P, Hildebrandt B, Sreenivasa G, et al. Hyperthermia in combined treatment of cancer. The Lancet Oncology 2002; 3:487–497.
  4. Alexander HR. Isolation perfusion. In: DeVita VT Jr., Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. Vol. 1 and 2. 6th ed. Philadelphia: Lippincott Williams and Wilkins, 2001.
  5. Falk MH, Issels RD. Hyperthermia in oncology. International Journal of Hyperthermia 2001; 17(1):1–18.
  6. Dewhirst MW, Gibbs FA Jr, Roemer RB, Samulski TV. Hyperthermia. In: Gunderson LL, Tepper JE, editors. Clinical Radiation Oncology. 1st ed. New York, NY: Churchill Livingstone, 2000.
  7. Kapp DS, Hahn GM, Carlson RW. Principles of Hyperthermia. In: Bast RC Jr., Kufe DW, Pollock RE, et al., editors. Cancer Medicine e.5. 5th ed. Hamilton, Ontario: B.C. Decker Inc., 2000.
  8. Feldman AL, Libutti SK, Pingpank JF, et al. Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy. Journal of Clinical Oncology 2003; 21(24):4560–4567.
  9. Chang E, Alexander HR, Libutti SK, et al. Laparoscopic continuous hyperthermic peritoneal perfusion. Journal of the American College of Surgeons 2001; 193(2):225–229.

Detoxification – One of the Body’s Primary Defense Mechanisms!

Toxic exposure, leaky gut, yeast, bacteria, parasites, nutrient deficiencies and food allergies all contribute to an increased antigenic and toxic burden.

The symptom picture of general toxicity includes increasing sensitivity to exogenous exposures, general malaise, pain, fatigue and headache. Joint and muscle pain and a poor exercise tolerance are also symptoms along with skin rashes, cognitive dysfunction, unilateral paraesthesia and paradoxical responses to medications.

Non-polar, fat soluble toxins are easily absorbed, but are not easily excreted. The body has developed enzyme systems to transform these toxins into more polar molecules, making them easier to eliminate. This bio-transformation may occur in the liver, intestines, lungs, kidneys and the skin.

There are two major pathways of liver detoxification. Phase I consists primarily of hydroxylation reactions involving cytochrome P450 enzymes – these are highly inducible with a wide genetic variability. Phase II consists of conjugation reactions.



Phase 1
Detoxification

Phase 1 detoxification transforms fat soluble compounds into water soluble compounds so the body can excrete them. P450 enzymes can neutralize compounds directly, or convert them into intermediate forms. Toxic intermediates are highly reactive (water soluble).

Phase 1 detoxification reactions involve hydroxylation, oxidation, dehydrogenation and epoxide hydration along with metabolic reductions, alcohol dehydrogenation and metabolic de-alkylation.

There are various substances that activate Phase I. Drugs such as alcohol, nicotine, phenobarbital, sulphonamides and steroids. Another is foods, mainly cruciferous vegetables, char-broiled meats, high protein diet and tangerines. Nutrients, specifically vitamin B1, B3 and vitamin C and herbs such as caraway and dill seeds also play a role. Environmental toxins like carbon tetrachloride, exhaust fumes, paint fumes, dioxins and pesticides are also included.

Inhibitors of Phase I detoxification includes foods such as naringenin (grapefruit juice), curcumin (tumeric), capsaicin (chili pepper), eugenol (clove oil) and quercetin (onions). Certain drugs may also inhibit Phase 1, specifically benzodiazepines, antihistamines, cimetidine and other stomach-acid secretion blocking drugs, ketoconazole and sulfaphenazole. Calendula officianalis, a botanical, may also be a factor, along with aging and bacterial toxins from the gastrointestinal tract.



Phase 2
Conjugation Reactions

These reactions consist of glutathione conjugation, amino acid conjugation (glycine, glutamine and taurine), sulfation, glucuronidation, acetylation and methylation.
 
The test procedure to assess a detoxification profile entails taking 200mg caffeine on waking. A saliva sample is then collected two and eight hours later. At bedtime 650mg aspirin and 650mg acetaminophen is taken and a urine sample is collected for the next 10 hours.
 
A fast Phase 1 and a deficient Phase II lead to a generation of toxic intermediates which can damage cells and exert systemic effects. The treatment goals are to reduce toxin exposure, increase antioxidant support and enhance Phase II conjugation, for example by supplementing with NAC, GSH, glycine, Ca-d-glucarate and cofactors etc.
 
A slow Phase 1 may be due to impaired detoxification ability. P450 inhibitors need to be ruled out, namely H2 blockers, birth control pills, SSRIs, heavy metal toxicity, naringenin, “Azole” antifungals, certain antibiotics, excess sugar, transaturated fats and possible iron deficiency. The treatment normally involves elimination of the inhibiting substances with nutritional and hepatic support. Nutrition for Phase II pathways should include indole-3-carbinol, cruciferous vegetables, garlic, rosemary and soy.
 
Cysteine to Sulfate Conversion
A normal to high cysteine level with low sulfate may mean low molybdenum, or hypochlorhydria: 

  • Cysteine dioxygenase to cysteine to sulphite.
  • Sulfite to sulfate (requires sulfite oxidase and a molybdenum dependent pathway).

Sensitivity to sulfites is another possibility. Vitamin B6 may need to be supplemented as it is required to convert cysteine to taurine and alpha ketoglutarate.


Candibactin-BR

Detox For A Healthy Immune System

Glutathione
Glutathione is composed of three amino acids; cysteine, glycine and glutamic acid and is a highly concentrated intracellular antioxidant. It is a sulfhydryl antioxidant, anti-toxin and enzyme cofactor. It neutralizes free radicals produced in Phase I reactions. As it is water soluble it is mainly found in the cell cytosol.

Causes of depleted GSH reserves include excess exposure to xenobiotics or gut derived toxins. Also, an excess production of free radicals due to up regulated CYP-450 activity, inflammation, trauma, infection, intestinal dysbiosis, radiation and ischemia may affect reserves. Insufficient nutrient cofactors and inadequate GSH precursors/impaired methionine metabolism may also be more causes.

Glutathione cofactors consisting of magnesium (recycles pyroglutamic acid back to GSH), vitamin B6, B12, B2 and folate assist in homocysteine metabolism. Vitamin C preserves intracellular GSH concentrations while serine (formed from glycine) is another cofactor.

Glutathione precursors involve reduced GSH and supplementing with N-acetylcysteine (NAC), L-methionine, glycine or L-glutamine. NAC is however considered the best oral precursor as it is the least flawed and the most cost effective (Alt Med Rev 1997; 2(3):155-176).

Glycine
Glycine is the main component of GSH. It is an inhibitory neurotransmitter involved in the synthesis of DNA, phospholipids and collagen. Salicylates and benzoate are detoxified primarily through glycination.

Causes of depleted glycine reserves may be due to insufficient glycine available and insufficient nutrient cofactors (cysteine, pantothenic acid and magnesium). These boost co-enzyme A which is required for activation of the metabolite to be conjugated. Underlying hepatic disease and genetic uniqueness may also deplete reserves.

Sulfation
Sulfation involves the conjugation of toxins with sulfur-containing compounds. Steroid hormones, thyroid hormones, certain drugs and xenobiotic compounds use sulfation as their primary route of detoxification. Bacterial toxins and environmental toxins also use the sulfation pathway.

Sulfation is the primary route for the elimination of neurotransmitters. Inadequate sulphate results in an accumulation of toxic metabolites which in turn causes degeneration of the nervous tissue. Poor sulfoxidation may therefore increase the susceptibility to Parkinson’s disease and motor neuron diseases.

The causes of depleted sulfation reserves include exposure to xenobiotics and free radicals, insufficient sulphate and nutrient cofactors (methionine, cysteine), and impaired sulfoxidation (cysteine/sulfate ratio). Underlying hepatic disease, an excess of molybdenum and vitamin B6 (100 mg/day) and genetic uniqueness may also influence reserves.

Glucuronidation
Many commonly prescribed drugs are metabolized through the glucuronidation pathway for example estrogens, melatonin, vitamins A, D, E and K. Glucuronidation is an important detoxification mechanism when sulfation or glycination is reduced or saturated. People with Gilbert’s syndrome (reduced bilirubin glucuronosyl transferase) are known to have decreased glucuronidation.

Beta-glucuronidase is an inducible enzyme elaborated by anaerobic E. coli, bacteroides, clostridia and peptostreptococcus. Elevated levels are associated with increased enterohepatic re-circulation of toxins, hormones, drugs and carcinogens. Broad spectrum antibiotics reduce beta-glucuronidase activity and intestinal reabsorption of estrogen (oral contraceptive pill). 

Insufficient CHO reserves (fasting or insulin insensitivity) cause depleted glucuronidation.  Free radical mitochondrial damage is another cause, as ATP is required for glucuronidation. Cofactor insufficiency, specifically L-glutamine, aspartic acid, vitamin B3, B6, iron and magnesium, as well as hypothyroidism are causes, and also the antibiotics chloramphenicol and novobiocin.

Conclusion
Detoxification is one of the body’s primary defence mechanisms. Challenges such as leaky gut, poor diet, toxic chemicals and environmental pollutants increase the toxic burden. Impaired detoxification leads to free radicals and affects many systems in the body. Utilizing the detoxification profile targets specific imbalances and allows for tailored intervention.

SNP (single nucleotide polymorphism)     :    
————————————————–

COMT: methyl donors (Homocysteine Lowering Formula, TMG, SAMe, B vitamins)

GSTM and /or GSTT: NAC, transdermal glutathione, IV glutathione drips

CYP 1A1 and CYP 1B1 abnormalities: I never do enhancing of phase I without II as well, therefore: I3C / DIM / sulphoraphane containing products
Beta-glucoronidase inhibition with calcium d-glucorate is of added benefit

CYP 17A1 same supplements as for CYP 1A1 and CYP 1B1

ER alpha: Add estriol (E3) and progesterone to HRT and I3C / DIM

Sult: Muti Mineral

SOD2:  glisodin with superoxide dismutase

MTHFR: I use TMG, SAMe and other methyl donors such as folate or Homocysteine Lowering Formula or Folinic Acid

Vitamin DR: Vitamin D levels target 60


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Dr Craige Golding

Pulsed Electromagnetic Therapy (PEMF)

Now Available At Dr Golding’s Medical Practice

Introduction What is frequency therapy? Frequency therapy is the use of frequency to help support health or eliminate disease. Frequency therapy is based on the principle of resonance. Everything in the universe has a resonant frequency, or natural frequency. When an object is exposed to its resonant frequency, that object begins to vibrate and if the frequency and intensity are correct, the object can self-destruct. This is the principle behind the crystal glass that shatters when a particular note is played or sung. 

Frequency therapy uses particular frequencies to stimulate healing or to destroy certain bacteria or pathogens that threaten health. What are PEMFs? PEMF stands for Pulsed Electromagnetic Fields. PEMFs have a frequency component and a magnetic component.     The frequencies are carried through the body and administered to the body via magnetic applicators. Pulsed electromagnetic fields can stimulate the cells, improve circulation, and offer a host of other benefits depending on the programs selected. The device and a MAT or other magnetic accessories are used to generate the magnetic field.

PEMF energy is a natural phenomenon. The body is electric and each cell relies on voltage to be able to function efficiently. The heart generates electromagnetic waves that travel throughout the body promoting health. When you are sick, cellular voltage is low. PEMF devices can stimulate the cells, providing much needed voltage to heal at cellular level. PEMFs can also help to support areas like circulation and they have even been found to help decrease inflammation.

The Rife PEMF device offers both frequency therapy and PEMF therapy thereby combining the benefits of both modalities. The device contains frequencies that are designed to support and promote healing and frequencies that are designed to help reduce threats to overall health, like pathogens and inflammation.

For a video demonstration of PEMF and how it travels through the body, please watch our PEMF in action video at www.rifepemf.com.


What Conditions Can
Be Treated with
PEMF?

There are over 500 medical studies on the use of PEMF therapy. Since most medical conditions can benefit from increased circulation, decreased inflammation, and improved cellular energy and metabolism, most conditions can benefit from PEMF therapy. PEMF has also been shown to speed wound healing and support bone-healing.

Studies on specific conditions include: Alzheimer’s disease, arthritis, diabetic neuropathy, phantom limb pain, general pain, circulation, inflammation, insomnia, and many more. Who Can benefit from PEMF Therapy? Anyone wanting to reduce inflammation, increase circulation, or improve overall health can benefit from PEMF.

PEMF therapy can benefit anyone, young or old, by supporting and promoting both short and long term health with very few negative side effects and without the risks of antibiotic resistance.
Who Should avoid PEMF Therapy? Since PEMF therapy uses magnetic and electrical frequencies for therapy purposes, individuals with devices that are sensitive to electro frequencies should avoid PEMF therapy. This includes individuals with a pacemaker, audio implants, cochlear implants, and intrathecal pumps.

PEMF therapy has not been proven safe for use in pregnancy and pregnant women should avoid using PEMF therapy although TENS applications have been used to reduce labour pain.
PEMF is also not suitable for young children.
PEMF has not been proven safe for epilepsy.
Individuals with cardiac disturbances should use PEMF with caution since the heart relies on electrical signals to function at optimal levels.


Can frequencies be
dangerous?

Many people are aware of the potential dangers of cell phone towers and other electronic equipment. The frequency spectrum ranges from a single hertz to terahertz. There are many frequencies within this spectrum that are dangerous, and even deadly, and there are many frequencies which have been shown to be Safe for medical use.  It is important to choose a device that has been proven safe for use by the local medical or safety authorities to make sure your machine is safe for you. Our device is legally licensed as a medical device. Do not be fooled by marketing hype that says a device does not need to be licensed. The licensing process is there to make sure you are safe. It is also now illegal to use an unlicensed device and sentence can up to 10 years imprisonment.
 

What is the difference between TENS, Rife, and PEMF?


TENS, PEMF, and Rife devices all use frequencies for medical purposes. Most authorities only classify devices that use frequencies for health purposes as “TENs Type Devices.” Generally speaking, a TENs device has a limited number of frequencies. A Rife device has a broader range of frequencies. A PEMF device uses magnetic and electrical frequencies to deliver the frequency to the body for healing purposes. 
 

What is the difference between Magnets and Rife PEMF Therapy?

A static magnetic is limited to one constant magnetic field. A condition like arthritis, for example, has numerous underlying factors that contribute to the condition. In the case of arthritis, factors that contribute to the condition include inflammation, pain, lack of circulation, an increase in toxins. and a breakdown of joint and muscle tissue to name a few. Each of these factors responds to different fields and frequencies. The Rife PEMF device has over 30 different frequencies designed to address some of the underlying factors responsible for arthritis.

Since a magnet creates one field, it may be useful for one or two underlying factors of the condition, but application is limited. That is why some individuals find magnetic therapy useful while others do not – since the underlying factors for each individual may be different.

Dr Craige Golding

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