Antimicrobial PDT (photodynamic therapy) Now Available

Antimicrobial PDT (photodynamic therapy) Now Available

Bacterial contamination and emerging infections such as resistant organisms, and viruses, combined with increased international travel pose a great risk. Pathogens like viruses and resistant bacteria, malaria, and chroni viral infections such as HIV and Hepatitis C for example need a reduction of blood components of the micro-organisms. The expectation of a pathogen reduction system is that it achieves high enough levels of pathogen reduction to reduce or prevent the likelihood of disease transmission while preserving adequate cell and protein quality.

In addition the system needs to be non-toxic, non-mutagenic and should be simple to use.

The micororganim / virus reduction Technology that we use, uses riboflavin (vitamin B2) plus UV (ultraviolet light) light to induce damage in nucleic acid-containing agents of the micro-organism. The system has been shown to be effective against clinically relevant pathogens and inactivates leucocytes without significantly compromising the efficacy of the product or resulting in product loss. Riboflavin is a naturally occurring vitamin with a well-known and well-characterized safety profile.

This therapy is offered at Dr Craige Golding Medical practice using low level laser light therapy intravenously with photosensitizers. The device used is the Weber Medical low-level light laser equipment with fibreoptic cables providing IV access.

Photodynamic inactivation (PDI) has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to pose a threat to public health and that bacteriophages are frequently used as models of mammalian viruses, it is important to know and understand the mechanisms and photodynamic procedures involved in their photoinactivation.

Please check the following publication from August 2019 for more details:
https://pubs.rsc.org/en/content/articlehtml/2019/pp/c9pp00211a?page=search

One of the best photosensitizers for the treatment of viral diseases is Riboflavin (Vitamin B2) which is available for intravenous infusion.

We already have good clinical data available with this protocol showing there are no side-effects for patients, and very good results in treatment of Malaria and Hepatitis B and C virus.  Riboflavin can be stimulated with UV light (370 nm) and blue laser (447 nm) for production of reactive oxygen species.

Riboflavin + UV Light (UVA and UVB):

  • Riboflavin modifies nucleic acids upon exposure to light
  • When applied to blood, this mechanism renders pathogens and leukocytes unable to replicate
  • Chemistry is not based on covalent modification
  • Riboflavin and its photo-products are non toxic and non-mutagenic and are naturally present in normal blood

By using the Weber medical technology, Riboflavin can be stimulated systemically in the blood by insertion of a sterile catheter in a 22 G cannula for targeting the virus in the blood and additionally this will lead to a resistance to the virus by having an effect on the destroyed damaged virus material.
Since the Corona virus mainly binds to cells in the respiratory tract the inner mouth can be treated locally by using a special mouth applicator with UV and blue laser as mentioned above.

In case of deeper infection a circular irradiating fiberoptic cable can be inserted in a suction catheter and can be used for treatment in the hypopharynx area.

In case of severe lung infection the special fiberoptic cable (1,5 mm soft plastic fiber) can also be inserted in a tube for intrabronchial application.

Riboflavin is already used successfully for disinfection of blood products to keep them virus free (see studies below and attached).

In the attached study of Keil et al. the efficacy of Riboflavin PDT with UV on Mers-Cov corona virus could already be demonstrated.

Background :

• Discovered at beginning of 20th century
• Neglected due to the discovery of antibiotics and lacking technology for clinical application
• Today: Continuous onset of multi-drug-resistant pathogens, stealth pathogens, viral pandemics
• 2005: Approval of first laser machine for systemic intravenous (IV) light application

Antimicrobial PDT is a new treatment option for infectious diseases with many favourable features:
– Efficiency against multi-drug-resistant pathogens
– No new resistances emerges
– Little side-effects
– Cost-efficiency.

Mechanisms of action :

  • Photosensitizer binds to microbes
  • “Light Activation“: Photosensitizer absorbs photons
  • Excitation of Photosensitizer to highly reactive states
  • Reaction with ambient oxygen: – Type I Photochemical Pathway: Generation of  reactive oxygen species – Type II Photochemical Pathway: Generation of singlet oxygen
  • Both species induce irreparable oxidative damages to microbes as they interact with numerous enzymes leading for example to the inhibition of protein synthesis and molecular alteration of DNA strands
  • Microbial death

Photosensitizers :
Riboflavin: • Vitamin B2 • Activated by Blue Light with a peak at 447nm
Curcumin: • Derived from Curcuma Longa • Excitation peak at 447nm (blue)

Hypericin: • Extract from St. John´s Wort • Excitation peak at 589nm (yellow)

Mirasol Pathogen Reduction Technology (PRT): Combination of Riboflavin and ultraviolet light as well as blue light for the reduction of pathogen loads in blood products (anti viral, anti bacterial and anti paracytic) is offered at Dr Craige Golding Medical practice

In vitro research :

In HIV research, several studies show a positive effect of PDT on HIV (Degar 1992, Hudson 1993, Lenard 1993, North 1993, Lavie 1995, Ben Hur 1997, Li 2011 etc.). In Germany, Hypericin was even tested by the famous Robert-KochInstitut: The researchers found an anti-HIV effect in-vitro, BUT only in combination with light.

Following effects on HIV have been observed:
– PDT inhibits HIV attachment and entry to human cells  early blockage of HIV replication – PDT can inactivate free viral particles – selective destruction of infected white cells. Two pathogen reduction technologies – methylene blue plus light and shortwave ultraviolet light – effectively inactivate hepatitis C virus in blood products Eike Steinmann, Ute Gravemann, Martina Friesland, Juliane Doerrbecker, Thomas H. Müller, Thomas Pietschmann and Axel Seltsam*

RESULTS: HCV was sensitive to inactivation by both pathogen reduction procedures. HCV in plasma was efficiently inactivated by MB plus light below the detection limit already by 1/12 of the full light dose. HCV in PCs was inactivated by UVC irradiation with a reduction factor of more than 5 log.

CONCLUSIONS: Pathogen reduction technologies such as MB plus light treatment and UVC irradiation have the potential to significantly reduce transfusion-transmitted HCV infections.

Multi-drug-resistant MRSA:

Maisch et al. examined penetration and antibacterial efficacy of XF73 (a cationic porphyrin PS) against MRSA using an ex vivo model.
Photoinactivation of pre-incubated S. aureus demonstrated >3 log10 reduction, while illumination after XF73 was delivered to the bacteria on the skin resulted in a approximately 1 log10 growth reduction independently of the antibiotic resistance pattern of used S. aureus strains.

Possible new treatment for malaria:

Abstract: Anti- microbial Photodynamic Therapy: A new treatment option for Malaria? Michael Weber, MD / Robert Weber, MSc / Martin Junggebauer, MSc / Habeeb Ali, MD Objectives: Evaluation of a treatment protocol consisting of anti- microbial photodynamic therapy (aPDT) and additional intravenous low-level-laser-therapy as a new treatment option for Malaria. Methods: 20 patients suffering from Plasmodium Falciparum were separated in one treatment group and one control group, both consisting of 10 patients. Patients in the treatment group received aPDT as well as intravenous low-level laser therapy. Patients in the control group received conventional therapy only.

Results: After 9 days, 88,9% of treatment group patients were completely parasite-free whereas the same holds true for only 50% of control group patients. Almost all symptoms could be alleviated more rapidly in the treatment group. Conclusion: The results indicate that the applied protocol can be an effective treatment option to treat Malaria caused by Plasmodium Falciparum. They strongly encourage further studies with bigger sample sizes.

Hepatitis C : First pilot data (Weber Medical Clinic, Germany):

  • 5 patients with HCV treated with Riboflavin and 447nm blue laser • Results: Noticeable decreases of viral loads in all treated patients • The effects became significant after 3-5 treatments
  • Even patients that had been treated with conventional methods for many years without noticeable effects reacted very positive to aPDT. After five treatments the viral load decreased by 70% in average

Lyme’s disease latest studies : Infectious disease caused by Borrelia bacteria which is spread by ticks • Early symptoms (stadium 1) may include fever, headache and tiredness

  • If untreated, chronic disease may develop with symptoms including chronic fatigue, facial paresis, joint pains, depression, severe headaches with neck stiffness, myocardial problems and co-infections due to weakened immune system (stadium 2 and 3)
  • It is estimated to affect 300,000 people a year in the United States and 65,000 people a year in Europe
    What do borrelia bacteria do?
  • They screw into collagen fibers in connecting tissue, leading to inflammation and acidity
  • Structure of connecting tissue is affected and immune cells are disabled
  • Vascular processes lead to circulatory disorders, nutrient deficiency in the affected tissue and loss of functions
  • Main problem: Resistance against antibiotics (especially intra-cellular bacteria* and cell wall-deficient (CWD) borrelia)
  • CWD borrelia: Antibiotics (i.e. Penicillin) lead to changes of form, properties and markers of the bacteria
  • Development of chronic lyme disease as antibiotics and the immune system cannot fight intra-cellular and CWD borrelia (bacteria can survive for several years)
  • Often connected to co-infections due to weakened immune system
    *Borrelia can hide in neuronal cells, fibroblasts, lymphocytes, macrophages etc
    Study Dr. I. Zuern, Germany (2016):
  • 3 groups with 10 chronic lyme patients each
    • Patients in all 3 groups received the following therapies:
    – Physical vascular therapy (Bemer) – Immunotherapy – Vitamins and additional natural supplements – Neural Therapy – Procain bases infusions – Oxygen therapy

Group B: Additional Yellow Laser 589nm + Hypericin (10-15 treatments, 2-3 times per week)

Group C: Additional 447 nm Blue Laser + Riboflavin (10-15 treatments, 2-3 times per week)

Diagnostics: Lymphocyte Transformation Test (LTT) : Detection of the activity of chronic, persistent infections based on pathogen-specific T cell response (Borrelia, Chlamydia, Yersinia, Giardia lamblia, Herpes viruses etc.)

  • The in-vitro test is based on the principle of antigen/allergen-specific induction of cell division in lymphocytes following contact with their «fitting« antigen
  • A positive reaction in the LTT indicates the presence of antigen-specific lymphocytes (memory cells) in the patient’s blood ( immune response to different borrelia antigens)
  • Activity of infection can be measured

Tested antigens: -Borr. sensu stricto – Borr. afzelii – Borr. garinii -Borr. OspC

Measurement of antigen-specific t-cells in patient‘s blood:

Stimulation index (SI) >3,0 positive. Stimulation index (SI) 2,0-3.0 boarderline Stimulation index (SI) <2,0 negative

Very favourable outcomes in studies using Antimicrobial Photodynamic therapy!

Outlook and moving forward :

  • Very promising results from first in-vivo studies on aPDT
  • Seems to work against bacterial, parasitic and viral infections
  • Larger patient populations necessary
  • Development of ultraviolet diode should bring additional benefit
  • Promising future due to increasing drug resistances

Intravenous Ultraviolet Light Therapy

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References :

• J Appl Microbiol. 2018 Apr;124(4):1017-1022. doi: 10.1111/jam.13638. Epub 2018 Jan 31.
Evaluation of 405-nm monochromatic light for inactivation of Tulane virus on blueberry surfaces.
Kingsley DH1, Perez-Perez RE1, Boyd G2, Sites J2, Niemira BA2.
Link: https://www.ncbi.nlm.nih.gov/pubmed/29144595
• Avicenna J Med Biotechnol. 2015 Apr-Jun; 7(2): 57–63.
Published online 2015 Apr.
The Effects of Ultraviolet Light and Riboflavin on Inactivation of Viruses and the Quality of Platelet Concentrates at Laboratory Scale
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483315/
• Riboflavin and ultraviolet light: impact on dengue virus infectivityArticle in Vox Sanguinis 111(3) • June 2016 with 145 Reads
Link: https://www.researchgate.net/publication/303883589_Riboflavin_and_ultraviolet_light_impact_on_dengue_virus_infectivity
https://en.wikipedia.org/wiki/Pathogen_reduction_using_riboflavin_and_UV_light in Wikipedia
• Published: 30 March 2019
Different photodynamic effects of blue light with and without riboflavin on methicillin-resistant Staphylococcus aureus (MRSA) and human keratinocytes in vitro
Link: https://link.springer.com/article/10.1007/s10103-019-02774-9
• The effectiveness of riboflavin photochemical‐mediated virus inactivation and changes in protein retention in fresh‐frozen plasma treated using a flow‐based treatment device
First published: 29 July 2014
Link: https://onlinelibrary.wiley.com/doi/full/10.1111/trf.12775
• Original Article
Role of Riboflavin- and UV Light-Treated Plasma in Prevention of Transfusion-Related Acute Lung Injury
• Free Access
Link: https://www.karger.com/Article/FullText/363205
• Hamblin R, Viveiros J, Changming Y, Ahmadi A, Ganz R, Tolkoff J,. helicobacter pylori accumulates photoactive porphyrins and is killed by visible light. Antimicrobial Agents and Chemotherapy, 2005; 49, 7:2822-2827
• Heine H. Lehrbuch der biologischen Medizin. Stuttgart: Hippokrates, 3. Auflage 2007
• Humpeler E, Mairbaurl H, Honigsmann. Effects of whole body UV-irradiation on oxygen delivery from the erythrocyte. Eur J Appl Physiol. 1982; 49:209-2014
• Karp G. Molekulare Zellbiologie. Heidelberg: Springer, 4. Auflage 2005
• Karu T. Ten Lectures on Basic Science of Laser Phototherapy. Gangesber, Sweden: Prima Books AB (2007)
• Karu T. The Science of Low-Power Laser Therapy. Amsterdam: Gordan and Breach Science Publishers, 1998
• Miley G, Christensen. Ultraviolet blood irradiation therapy: Further studies in acute infections. American Journal of Surgery. 1947;73(4):486-493.
• Miley, G. Effacacy of ultraviolet blood irradiation therapy and control of Staphylococcemias. American Journal of Surgery. 1942;64(3):313-322
• Zuern, I. (2016): Pilot Study on Treatment of Chronic Lyme Disease with Yellow and Blue Laser
• Goodrich, Raymond et al, 2011: Pathogen Reduction Technology Treatment of Platelets,
• Plasma and Whole Blood Using Riboflavin and UV Light. Published in: Transfusion medicine and Hemotherapy: 2011;38:8–18
• Goodrich et al., 2005: Patent Application Publication, Pub. No.: US 2005/0282143 A1, United States. Pub. Date: Dec. 22, 2005
• Hamblin, MR; T Hasan (2004). “Photodynamic therapy: a new antimicrobial approach to infectious disease?”. Photochem Photobiol Sci 3 (5): 436–450. doi:10.1039/b311900a.PMC 3071049. PMID 15122361 • Miley, G.: The Knott Technique of ultraviolet blood irradiation in acute pyogenic infections. New York State Journal of Medicine. 1942: 38- 46.Pathogen Deactivation
• Ramabhadran TV, F. T. (1976). In vivo induction of 4-thiouridine-cytidine adducts in tRNA of E. coli B/r by near-ultraviolet radiation. Photochem Photobiol, 23(5), 315-21.
• Ramabhadran TV, J. J. (1976). Mechanism of growth delay induced in Escherichia coli by near ultraviolet radiation. PNAS, 73(1), 59-63.
• Weber et al. (2010): Intravenous Laser Blood Irradiation: Introduction of a New Therapy

The Real Story Behind High Dose Vitamin C

The Real Story Behind High Dose Vitamin C

The typical diet of modern humans does not consist predominantly of Vitamin C-rich vegetables.

Although people live reasonable long lives with this limited intake, they increasingly suffer degenerative disease and a lower quality of life. This unnecessary suffering might not happen if the lost gene were still present (the lost gene is for the ability to synthesize vitamin C). Our inability to make our own ascorbate means that each newborn baby comes factory-equipped with, if not an inborn vitamin C deficiency, a vitamin C dependency.

The health benefits of vitamin C

The genuine vitamin C story has become clearer over recent years, as claims for unique health benefits of Vitamin Care are consistent with the available evidence. There is little scientific support for the idea that low (RDA level : recommended daily allowance) doses of ascorbate are optimal for humans. Antioxidants like vitamin C are essential for life because disease processes almost invariably involve free radical attack, which antioxidant defences can counteract.

People visiting a physician expect to receive clear, unbiased information about what ails them and its treatments. More importantly, they need to know what they can do to prevent disease. Patients would like to have the information necessary to make informed choices, but in many cases, this information is not provided, and even doctors are often unable to evaluate the information they need to make decisions that are optimal for patients interests. People often disregard the advice of conventional experts and supplement their diet with gram-level doses of vitamin C and other antioxidants.

Gram-levels of vitamin C may prevent many diseases, but much higher doses are required fir treatment of illness. The massive doses needed for therapy are often greeted with disbelief. When doctors are informed that 50-100grams (50000-100000mg) of vitamin C per day may be required to treat a common cold, their scepticism is transferred from the efficacy of the treatment to the size of the dose. Most clinical studies have considered doses of a single gram. A dose 100 times larger has very different properties.

One reason for the vitamin C controversy is contradictory clinical results from trials that use inadequate doses, doses that are 100 times too small and have consistently broken the basic rules of pharmacology. For as analogy, imagine a study in which 20000 fertile young women are placed on the contraceptive pill to prevent pregnancy. The researchers want to show that the pill has no effect, so they give one pill a month, instead of one a day, as designed. Control subjects take one sugar pill (placebo) per month. Now, suppose the results of this five-year trial indicate that, when taking a contraceptive pill once a month, the women became pregnant at the same rate as those on the sugar pill. No reasonable person would accept the claim that “the trial shows the pill does not prevent pregnancy.” You cannot expect a daily pill given monthly to have the same effect as the daily dose. However, this methodology is equivalent to studies of “high-dose” vitamin C, which purported to show it is ineffective.
An optimal intake of Vitamin C is the amount that prevents disease while minimizing the potential risk. It is a huge assumption to think that an intake to prevent acute scurvy will be adequate to prevent other diseases. Furthermore, there is substantial evidence that the intake of vitamin C needed to prevent chronic illness is much greater than the RDA (recommended daily allowance).

Unfortunately , direct studies on chronic disease and high-dose vitamin C intakes have not been undertaken, so we have to base our conclusions on an insufficient knowledge base. Typically, prospective studies provide the most direct information. In a prospective study, Vitamin C intake is estimated in large numbers of subjects, who are then tracked over time to see if they develop specific chronic diseases. Such studies are expensive and often and often imprecise. For example, the vitamin intake may be estimated by a questionnaire and approximated from typical proportions found in particular food items – fresh, organic carrots contain more vitamin C than those found in cans, for example. To get an accurate estimate of the optimal intake, it would be necessary for these studies to include intakes of vitamin C ranging from 50mg up to at least 10000mg/day, and this has not been done.

Some researchers suggest strangely that vitamin C from food is somehow more effective than the same molecule contained in supplements. However, an alternative explanation is that the methods used to estimate vitamin C intake from food have limited accuracy. Another possible explanation relates to the fact that we eat several times a day and vitamin C intake is released from food more gradually than from supplements.

Some beneficial effects of Vitamin C include

  1. cardiovascular disease reduction
  2. osteoporosis reduction
  3. less stretch marks
  4. cancer reduction
  5. numerous other health benefits.

Mechanisms of working :

a) Direct cancer killing effects in vitamin C sensitive subjects
b) Strengthening of connective tissue resulting in less invasion and less spread of cancer
c) Immune system support
d) Patients feel much better when on vitamin C compared to subjects with out
e) Strengthening of connective tissue and the matrix results in an effective therapy in cancer patients (Dr McCormick appears to have been the first to connect scurvy with predisposition to cancer.)

Dr McCormick considered vitamin C to be a pivotal therapeutic nutrient. He suggested that vitamin C could act both as an antioxidant and, occasionally, as an oxidant within the body.

Vitamin C’s oxidation-reduction effects provide a powerful chemotherapeutic action, especially when given in large, gram-level doses at hourly intervals (see references attached from Vitamin The real story by Andrew Saul PhD and Steve Hickey PhD. )

Furthermore the decline in death rates from infectious disease is generally attributed to sanitation, hygiene, and unspecified improvements in nutrition.

The Case for
High Vitamin Doses

Dr Pauling considered how animals use vitamin C.  Animals that synthesize Vitamin C make relatively large amounts; for example, rats reportedly make 70mg per kilogram of body weight each day.   If a rat is stressed the amount of ascorbate it produces increases, to about 215mg per day.  However this is insufficient to maintain vitamin C levels in sick animals, and as blood levels fall, urinary excretion increases by a factor of ten. An injection of vitamin C – a dose roughly equivalent to about 5grams (5000mg) in a human-restores the plasma ascorbate level, blood pressure, and capillary perfusion to normal, while inhibiting bacterial growth.

Other animals also increase their vitamin C production when stressed. A plausible explanation is that sick animals increase both the manufacture of Vitamin C and its excretion.    The rate of ascorbic acid production in the rat is equivalent to a dose of 5 grams to 15 g per day, given intravenously to a 154 pound (70kg) adult human. Similar rates of production are found in goats and other animals.    Domesticated cats and dogs produce somewhat less (human equivalent 2.5 grams).    By way of comparison, the RDA in the United States is less than 0.1 grams per day, between 50 and 150 times lower.   Furthermore, oral vitamin C is only partly absorbed.

A direct comparison between the amounts required by animals and humans could be misleading.  Humans might have evolved to need less, for example. Dr Pauling used an evolutionary argument and estimated that the amount of vitamin C in 110 raw plant foods, supplying 2500 calories, is at least 35x the RDA.  However there is little data on the diet of early man or other mammals.    While it is likely that plants 40 million years ago had similar levels of Vitamin C to those we find today, we do not have direct measurements.    Our ancestors may have been largely vegetarian, though we cannot be certain about this.

Animals that do not synthesize vitamin C may eat a vegetarian diet, providing a high level of the vitamin.  However, we cannot be sure that this is always the case as we do not have a complete list of such animals.    We do know that primates, other than humans, consume large amounts of vitamin C in their mainly vegetarian diet.

Dr Pauling became convinced that there was a scientific case for high doses of vitamin after listening to Dr Irwin Stone’s ideas. According to dr Stone. People need high dose vitamin C in large quantities to deal adequately with infection and stress.   Drs Stone and Pauling thought vitamin C, as ascorbic acid, is required in the diet because of an identifiable genetic mutation, which could be classed as an inborn error of metabolism.

There is no supporting evidence that “vitamin C complex containing bioflavonoids” is superior to L-ascorbic acid.    Suggestions that vitamin C is an ill-defined mixture of natural substances is unscientific, although it may be profitable to the commercial organizations concerned.

People consuming the low RDA levels of vitamin C may be considered deficient.    Authorities who claim that we only need such small amounts should be required to provide solid data to show that low doses are optimal. Unless such data is produced, official advice may be subjecting millions of people yo unnecessary ill health.    There is a bias at the heart of conventional nutritional advice. The original hypothesis for a vitamin was that it was a substance required in small amounts to maintain good health.    This definition has carried through into modern medicine and it has come to be regarded as fact.  People have forgotten that the idea that vitamins were needed in only small amounts was a relative measure, comparing the amount of vitamins to the proportion of fat, protein and carbohydrates in typical foods.  We are nowin the unfortunate position where the idea has become a medical dogma.

For decades, it was assumed (without any supporting evidence) that acute scurvy was the only vitamin C deficiency disease.   The idea that long-term deficiency could result in chronic illness, such as cataracts, heart disease, or arthritis, was largely ignored because there was no “proof” for this suggestion.  Dr Pauling argued for an increased requirement for vitamin C, using comparable biochemistry and evolutionary data. He believed that people had enough vitamin C in the diet to prevent them dying or becoming sick from acute scurvy, but insufficient to prevent disease in the longer term.

Dr Pauling brought the claims for high-dose vitamin C to the public and named a few form of nutritional therapy – orthomolecular medicine.    After a stellar career as one of the greatest scientists ever, he was happy to be known as “the Vitamin C man.”

These and other scientists and medical doctors have fought over the decades to make a case for the high-doses to fight disease.    While they remain marginalized by the conventional medical community, their courageous struggle has brought the many benefits of Vitamin C to the attention to a wider public and, in the process, saved many from needless suffering.

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011 718 3004 / 011 483 1080

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Internet resources :

  1. Journal of Orthomolecular Medicine (free full-text papers)
    http://orthomolecular.org/library/jom/
  2. Oregon State University’s Linus Pauling institute
    http://lpi.oregonstate.edu/
  3. Frederick R Kleiner’s book Clinical Guide to the use of vitamin C
    www.seanet.com/-alexs/ascorbate/198x/smith-lh-clinical_guide_1988.htm
  4. C for yourself
    www.cforyourself.com
  5. Vitamin C Foundation
    www.vitamincfoundation.org/
  6. Ascorbate Web
    www.seanet.com/-alexs/ascorbate
  7. Irwin Stone’s book The Healing factor : Vitamin C Against Disease
    http://vitamincfoundation.org/stone/

Cognitive Decline Affects Millions

COGNITIVE DECLINE AFFECTS MILLIONS of people around the globe

Early Alzheimer’s disease and its forerunners, MCI (mild cognitive impairment) and SCI (subjective cognitive impairment) should be tested for everyone over 45.

At our centre we run full diagnostics and therapeutics for Alzheimer dementia and other forms of cognitive decline. A new course on the diagnostics and therapeutics will soon be available to practitioners as well on Goldinginstitute.com

In terms of diagnostics we include (and not limited to) ;

  • Mini-mental and MoCa (Montreal cognitive assessment testing)
  • Full blood testing…conventional and functional lab testing
  • Chronic inflammatory response syndrome testing
  • Immune function testing
  • Hormone testing
  • Gut function testing
  • Dutch test analysis
  • GI map testing
  • Gene testing
  • AoeE4 gene testing
  • Methylation testing
  • Neurotransmitter testing
  • Telomere testing
  • Heavy metaltesting via labs and via oligoscan testing
  • HTMA (hair tissue mineral analysis testing)
  • Microbiome testing
  • Viome testing

Treatments include :

  • Psychological support to patient and family
  • Mitochondrial medicine
  • Nutraceutical therapies
  • Nootropics
  • Nutritional Medicine
  • Ketoflex dietary approach and ketone testing with ultra-precision.
  • Functional and Integrative Medicine
  • Detoxification therapies
  • IV nutrient therapies
  • Low level light laser therapy transcranially and intravenously
  • IV nutrient therapy
  • Heavy metal detoxification
  • Ozone therapy
  • Hyperbaric oxygen therapy
  • Hormone balancing using bio-identical hormone therapy
  • Regenerative medicine and stem cell therapy
  • Mould detoxification
  • Neurofeedback referrals

ApoE Ɛ4 GENOTYPING

Do you have one or two copies of the ApoE Ɛ4 Gene?
Genetic tests can tell!

YOU CAN IMPROVE MEMORY LOSS
Genes are the predisposition, NOT the determinant! Lifestyle matters

Some experts call Alzheimer’s type 3 diabetes due to a link between diabetes, obesity and Alzheimer dementia later

Millions of people all over the world have Alzheimer disease. Females outnumber males 2:1 and the number of new cases is expected to rise exponentially. For most Alzheimer’s specialists the disease is caused by a buildup of amyloid plaque, and another protein (Tau), which interferes with the functioning of the neurons. Because amyloid, (and tau protein), is seen as the major pathology present in AD, the goal of actual treatments has been consistent in giving a a drug to remove the plaque. But so far, there have been more failures than successes. Several companies are investigating drugs that target beta-amyloid, the protein considered by many to be the main culprit in Alzheimer’s not even making it out of the testing phase for 96% of them.
Of 244 AD drugs tested between 2000 and 2010, only one was approved.

If you have Alzheimer’s disease you know that you have been labeled with an almost universally fatal disease. if you have one copy of ApoE Ɛ4, you have an increased risk for Alzheimer’s disease over someone who has zero copies; and if you have two copies, of course that’s increased further and it’s very likely that you will develop it during your lifetime. Fortunately, entirely new thinking about dementia is emerging from the field of functional and Integrative medicine. Based on recognition that the disease process contributors may include chronic inflammation, insulin resistance, diabetes, and obesity; gluten sensitivity; leaky gut; refined carbs; trans fats; chronic emotional stress; lack of exercise; nutrient-depleted diets; toxicities such as metal and mold toxicities; sleep problems; microbiome dysregulation; smoking; dental infections; exposure to environmental toxins; mycotoxins; infection with Borrellia (Lyme), Herpes, Babesia, and other common chronic infections.

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We Identify The Subtypes And Source Of Your Cognitive Decline

Dr Golding has qualification and certification in The Bredesen Re CODE ® Protocol

A Giant Step Forward for Alzheimer’s and Cognitive Decline

Today , there is a new and proven approach to treating those with Alzheimer’s disease. Developed by Dale E. Bredesen, MD, – known as the Bredesen Protocol TM– after thirty years of research on Alzheimer’s disease.

Dr. Dale Bredesen, co-founder of MPI Cognition, is an internationally-recognized expert in aging and neurodegenerative diseases. He earned his MD at Duke University, served as Chief Resident in Neurology at University of California, San Francisco (UCSF), was an NIH Postdoctoral Fellow in Nobel laureate Stanley Prusiner’s lab at UCSF, held faculty positions at UCSF, UCSD and UCLA, and was the founding President and CEO of the Buck Institute for Research on Aging. He has authored the book The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline.

The Memory Loss Recovery Program

Our unique program at the Golding Institute, and Dr Golding’s medical practice utilizes the tools of The Functional Medicine Matrix, advanced laboratory testing, Diet and supplements, Cutting-edge Technology for cognitive remediation, non invasive neurostimulation, Physical therapy, occupational therapy and a team of specialists to guide you on your journey.

We Identifies the root causes of your illness:

  • Identification of specific nutrient markers, antioxidant, inflammatory messengers, hormones, and signs of toxin exposure.
  • Full Neuropsychological assessment.
  • Physical and fonctionnal assessment.
  • 3D Brain imaging with volumetrics and qEEG.

YOU CAN REVERSE MEMORY LOSS

Most patients treated scored higher in their Cognitive Assessment tests

IMPROVED HEALTH without EXPERIMENTAL DRUGS

This Is How You Will Improve

1.Nutrition and supplements
You will meet with our team to discuss nutrition and diet recommendations and meet for follow ups.
A comprehensive supplement program will be tailored to your needs based on history and lab investigations

2.Cognitive Training
You will have a personalized cognitive brain training to stimulate, train, and rehabilitate the main
cognitive skills (perception, attention, memory, reasoning, etc.) and the components that make them up.

3.Neurostimulation and neurofeedback referrals will be arranged where necessary
You will receive non invasive Brain stimulation sessions to modulate cortical excitability and
inducing lasting effects including low level light laser therapy transcranially and intravenously

4.Physical Training, yoga and meditation referrals
5.IV nutrient therapy
6.Detoxification of aluminium, mercury, copper and other heavy metals
7.Niacin and infra red saunas
8.Hyperbaric oxygen therapy
9.Ozone therapy intravenously

Benefits of Ozone Therapy!

a. Inactivation of bacteria, viruses, fungi, yeast and protozoa: Ozone disrupts the integrity of the bacterial cell envelope through oxidation of the phospholipids and lipoproteins. In fungi, ozone inhibitscellular growth at certain critical stages. With viruses, theozone damages the lipid envelope and interrupts there productive cycle by disrupting the virus-to-cell contact with peroxidation.

b. Enhancement of circulation: in circulatory disease, a clumping of red blood cells hinders blood flow through the small capillaries and decreases Oxygen absorption due to reduced surface area. Ozone reduces or eliminates clumping and red cell flexibility is restored, along with Oxygen carrying ability. Oxygenation of the tissues increases as the arterial partial pressure increases
and viscosity decreases. Ozone also oxidizes the plaque in arteries, unclogging the blood vessels.

c. Stimulation of Oxygen metabolism: ozone causes an increase in the red blood cell glycolysis rate, stimulating (2,3-DPG) which leads to an increase in the amount of Oxygen released to the tissues. There is a stimulation of the enzymes, which act as free radical scavengers and cell wall protectors: glutathione peroxidase, catalyse, and superoxide dismutase. Ozone activates the Krebs cycle by enhancing oxidative carboxylation of pyruvate, stimulating production of ATP.

d. Formation of peroxides: ozone reacts with the unsaturated fatty acids of the lipid layer in cellular membranes, forming hydro peroxides. Lipid peroxidation products include peroxyl radicals, singlet Oxygen and ozonides.

e. Dissolution of malignant tumours: ozone inhibits tumour metabolism. In addition, ozone oxidizes the outer lipid layer of malignant cells and destroys them through cell-lysis (break-down). Ozone stimulates conversion of L- arginine to citrulline, nitrite and nitrate by phagocytes, acting on tumours.

10. Live blood analysis and suitable treatments

11. PEMF (pulsed electromagnetic frequency therapy with Rife machine)

12. Coaching : You will have ongoing consultations with a trained Alzheimer’s/dementia coach to discover, define, and move towards your desired goals and track progress

How Do We Do It? Assess

  • Full Neuropsychologic Assessment
  • Most advanced laboratory testing
  • Functional assessment
  • Medical assessment
  • Physical Evaluation
  • Brain Imaging

Transform

  • Nutrition and supplements
  • Stress management
  • Cognitive training
  • Physical training
  • Neurostimulation
  • Coaching

Maximize

  • Monitor Lifestyle Factors
  • Optimize Your Diet
  • Optimize Neuroplasticity
  • Mend Your Mitochondria
  • Avoid Toxic Expansion
  • Control Inflammation

Multi-Functional Assessment

We use advanced testing, genomics, neuro imaging, neuropsychologist testing for accurate diagnosis.

 

1 / Conprehensive Neuropsychological Testing

We will conduct an in-depth assessment of skills and abilities linked to brain function. The evaluation measures such areas as attention, problem solving, memory, language, I.Q., visual-spatial skills, academic skills, and social-emotional functioning.

2 / Medical

A comprehensive review of your symptoms, your history, your neurological examination, and any testing that has been done up to this point. So many patients we see have been given the wrong diagnosis! We use precision medicine laboratory testing .We may include MRI with 3D Volumetric Analysis, Positron Emission Tomography, EEG and biomarker identification and quantification.

3 / Lifestyle and Functional Assessment

A registered Occupational therapist will help patients live life to its fullest by adapting the environment and focusing on what they can do to maximize engagement in activity (occupation), promote safety, and enhance quality of life. It is essential to help clinicians and caregivers make decisions regarding the choice of suitable interventions and to monitor disease progression.

The Bredesen Re CODE ® Protocol
A Giant Step Forward for Alzheimer’s and Cognitive Decline

PRE-VISIT: Free Conference Call With A Senior Team Member

  • We collect a brief history of the problem that your chief concern.
  • We discuss your medical record records if any
  • We explain additional testing/evaluation needed
  • We explain the content of the program
  • We explain the costs

Day 1

You will meet with Dr Golding and /or our therapists for full cognitive assessment. The Physician / practitioner reviews your MRI and or scans. and lab results and discusses medical outcomes and a plan for a nutraceutical regimen correct nutrients, oxidative stress markers, and inflammation.

Day 2

You will meet with a physician for your:

  • Medical history
  • Neurological physical examination
  • Functional medicine timeline and matrix.

Months 1

You will come once to twice a week for follow-up and treatments
*Telemedicine Visit As Needed

Months 1-6….flexible appointments to review cognitive functioning and continue our various treatment modalities.

Long term follow up essential.

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Contact Dr Golding Today
011 718 3004 / 011 483 1080

Visit Dr Golding’s Online Store

Infrared Sauna, an Investment in Your Health!

Infrared Sauna, an Investment in Your Health!

Owning an infrared sauna is an investment in your health we are confident you won’t regret.

Having infrared sauna can help:

  • Assists Weight Loss Goals & Weight Management
  • Improve Fitness, Firming & Toning
  • Increase Energy & Endurance
  • Ultimate Relaxation, Stress Relief
  • Sleep Management, Meditation & more…

Watch above and learn all about SaunaWellness Infrared Sauna it takes less time than you might think and we have this available at Dr Craige Golding Medical practice.

Make this your year to invest in your health…

There has never been a better time to ‘Help increase and improve whole body health’

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Visit Dr Golding’s Online Store