A Novel Nutritional Approach to Resolve Inflammation, Specialized Pro-resolving Mediators (SPMs)

Posted On October 22, 2020 at 8:24 am by / No Comments

Specialized Pro-resolving Mediators (SPMs), a Novel Nutritional Approach to Resolve Inflammation

Inflammation is an immune response to insults such as injuries (cuts, wounds, etc.) infections (bacterial, viral, or fungal), or unhealthy dietary patterns. Although acute inflammation is a normal, protective response, it can give rise to chronic inflammation if left unresolved.

Is Inflammation Harmful Or Helpful to Your Health?

Acute inflammation is a localized, protective immune response of the host in attempt to immediately eliminate invading pathogens and/or repair injured tissue.

Unhealthy dietary patterns have also been linked to inflammation

Ideally, an acute inflammatory response is a self-limited process, leading to resolution that enables tissue healing and a return to homeostasis (restoration to the previous normal condition.

Acute inflammation, if left unresolved or uncontrolled, can give rise to a prolonged state of chronic inflammation that causes damage to the host, resulting in pain and/or dysfunction.

Many chronic diseases such as cardiovascular disease, arthritis, diabetes, metabolic syndrome, inflammatory bowel disease, periodontal disease, asthma, and age-related macular degeneration, as well as some neurological disorders, have been linked to chronic inflammation.

Furthermore, aging may be associated with a mild pro-inflammatory state that has been termed “inflammaging.”

Whether the acute inflammation is resolved will determine its biological effect.

Key point: Acute inflammation is a normal defense response.

How effectively it resolves determines whether inflammation becomes harmful or helpful to health. The ideal outcome is complete resolution.

  • Groundbreaking research has discovered that SPMs are produced at the inflamed site after the initial inflammatory response, and function as “resolution agonists,” orchestrating resolution to facilitate the return to homeostasis and tissue healing.
  • An important key to controlling/resolving inflammation and subsequently preventing chronic inflammatory conditions lies in SPMs and their pro-resolving properties.
  • SPMs are produced from long-chain polyunsaturated fatty acids—especially EPA and DHA—illustrating the importance of appropriate nutrition in the body’s resolution of inflammation.
  • Although EPA and DHA are metabolic precursors of SPMs, SPMs are directly responsible for resolution activities whereas EPA and DHA are involved in other beneficial biological activities. Therefore, SPM supplementation may represent an effective approach in supporting resolution.

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Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease.

Inflammation exists in other settings as well, such as pre- and post-operative settings where healing will be necessary.

Metagenics Institute asks Dr. Charles Serhan of Harvard Medical School if there is any data regarding pre- and post-operative use of SPMs for improved healing outcomes.

Dr. Serhan responds that there is, indeed, data supporting that indication of SPMs. SPMs will not interfere with coagulation. Only one SPM (E1) has an influence on platelets, which influences the second wave of platelet aggregation, for a beneficial effect. Furthermore, SPMs can help with pain reduction.

They can assist with recovery from pain and expedites wound healing and recovery.

Credit :  Insights from the Metagenics Lifestyle Summit 2015: Charles Serhan, PhD

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