Curcumin – The Most Powerful Medicine

Curcumin, The Most Powerful Medicine

Curcumin’s benefits are so diverse that they affect virtually every organ system in the body. It’s no accident that the National Institutes of Health has funded numerous studies investigating curcumin, which include diverse applications such as treatment of cystic fibrosis, the feasibility of controlling the autoimmune disease, scleroderma, and various cancer chemoprevention trials.23 Meanwhile, pharmaceutical companies around the world are actively working to derive patentable molecules based on curcumin, which they hope to market, at great profit, as anticancer treatments.24

Among other activities, curcumin has demonstrated antibacterial, antifungal, antiviral, anti-inflammatory and antioxidant capabilities.18 It’s even showing great promise in the fight against the most common genetic disorder in Caucasians, cystic fibrosis.14 To this list, add powerful anticancer protection, cardiovascular protection, and protection against neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases.8,16,25-29 Additionally, curcumin shows promise as a potential treatment for multiple sclerosis,7 and may protect against cataracts30 as well as reverse some of the damage associated with the high blood sugar levels that characterize diabetes.31 Curcumin also shows great promise as a treatment for skin disorders such as psoriasis, and in the treatment of wounds.9, 32

Powerful Cancer Protection

Scientists usually go out of their way to avoid hyperbole when describing the subjects of their inquiries, but curcumin’s amazing properties evidently tempt even
the most staid researcher to throw caution to the wind. “Curcumin appears to possess all the desirable features of a desk-designed, multipurpose drug,” wrote one research team, recently.33 Other investigators focused on promising anticancer activity. “Curcumin… has emerged as one of the most powerful chemopreventive and anticancer agents,” wrote Indian researchers last year. “Its biological effects range from antioxidant [and] anti-inflammatory to inhibition of angiogenesis, and [it] is also shown to possess specific antitumoral activity.”27 Although

anticancer drugs weaken the immune system, curcumin actually enhances it, 12,34-43 acting as an “immunorestorer.”34 It’s little wonder, then, that cancer prevention and treatment has emerged as one of the most avidly researched aspects of curcumin’s potential benefits.

Writing in Cancer Letters, American scientists noted recently, “Pre-clinical studies in a variety of cancer cell lines including breast, cervical, colon, gastric, hepatic, leukemia, oral epithelial, ovarian, pancreatic, and prostate have consistently shown that curcumin possesses anticancer activity in vitro and in pre-clinical animal models.”44 Other investigators wrote: “Carcinogenesis encompasses three closely associated stages: initiation, progression, and promotion. *Curcumin+ has been shown to possess anti-inflammatory, antioxidant, and antitumor properties. [It] has also been shown to be beneficial in all three stages of carcinogenesis.”43

SPECIFIC ANTICANCER MECHANISM DISCOVERED

In mid-2007, scientists at the University of Alabama at Birmingham published a report in the journal Cancer Research, detailing at least one of perhaps many mechanisms by which curcumin functions as an anticancer agent. The investigators grew prostate cancer cells in the laboratory, and exposed them to varying concentrations of curcumin. The curcumin
reduced the cells’ production of a protein known as MDM2, which is associated with the formation of malignant tumors. Simultaneously, curcumin prompted the cells to produce another protein associated with the promotion of programmed cell death (apoptosis).27 Like NF-kB, an inducer of inflammation, MDM2 has been suggested as a novel target for human
cancer therapy.

To test curcumin’s effects in a live model, the scientists grafted human prostate cancer cells onto special mice, which subsequently developed tumors. The mice were then fed either curcumin or a placebo, five days a week, for four weeks. Afterwards, curcumin-fed mice were further divided into three test groups. One group continued to receive curcumin alone, while another received curcumin plus the cancer chemotherapy drug, gemcitabine. The final group received curcumin plus radiation treatment.

“Curcumin inhibited growth of [human-to-mouse prostate cancer grafts] and enhanced the antitumor effects of gemcitabine and radiation. In these tumors, curcumin reduced the expression of MDM2,” wrote the researchers. This suppression, or “down-regulation” of MDM2 expression was declared to be a newly discovered mechanism by which curcumin exerts its anticancer activity. MDM2 down-regulation by curcumin “may be essential for its chemopreventive and chemotherapeutic effects,” the scientists
concluded.27

It’s interesting to note that epidemiological studies show the incidence of prostate cancer among men in India to be among the lowest in the world. One recent study estimated that the annual prostate cancer incidence rate in India ranges from 5.0 to 9.1 per 100,000/year. In contrast, among whites in the United States, the incidence rate is 110.4 per 100,000/year—more than ten times higher compared with men from India. The rate for African Americans is even higher.45 Perhaps not coincidentally, Indian men’s consistent intake of turmeric, in the form or curry, is among the highest in the world. The average intake of turmeric in the Indian population is 2-2.5 g/day, providing 60-200 mg curcumin.

Pancreatic Cancer

Curcumin has also been shown to enhance the efficacy of the chemotherapy agent, gemcitabine, in the treatment of pancreatic cancer. Although it is currently the best treatment for this aggressive cancer, gemcitabine often loses its effectiveness as cancer cells develop resistance to the drug. Scientists from the University of Texas M.D. Anderson Cancer Center showed recently that curcumin prevents the development of this resistance, in both cultured pancreatic cancer cells and in living animal models of the disease. “Overall, our results suggest that curcumin potentiates the antitumor effects of gemcitabine in pancreatic cancer by suppressing proliferation, angiogenesis, NF-kB, and NF-kB-regulated gene products,” concluded the scientists.46

COLON AND BREAST CANCERS

Curcumin’s efficacy against colon cancer has received great attention, primarily because curcumin’s bioavailability has been less of an issue, given that the colon is exposed to curcumin as it passes through the digestive tract.17 Its excellent tolerability and safety have been demonstrated in five Phase I clinical trials in colon cancer, and Phase II trials are currently enrolling patients.44 British investigators showed recently that curcumin interferes with the proliferation of various types of colon cancer, and that it enhances the efficacy of an existing chemotherapeutic agent, oxaliplatin.47

Curcumin’s potential role in the fight against breast cancer is nothing short of remarkable. Italian researchers reported recently that curcumin is effective against a common variety of breast cancer cells and a mutant line of cells that has developed resistance to common chemotherapy drugs. “Through analyses of the effects on cell proliferation, cycling and death, we have observed that the antitumor activity of curcumin… is at least equal in the *multi-drug-resistant breast cancer] cell line compared to the *ordinary breast cancer cell line+,” wrote researchers.48 This efficacy also held true for a type of multi-drug-resistant leukemia cell.

The Italians’ research indicates that curcumin seems capable of adapting its anticancer activity according to need. “Remarkably,” wrote the scientists, “*curcumin and one of its derivatives+ appeared to modify their molecular effects according to the diverse gene expression patterns existing in the [multidrug-resistant and ordinary breast cancer cell line]. Clearly, the structure and properties of curcumin can form the basis for the development of antitumor compounds…”48

Novel Curcumin Formulation:
What You Need To Know!

  • One of today’s most promising natural disease-fighting agents is curcumin. Derived from the curry spice turmeric, curcumin has been used for millennia to target disease and promote good health.
  • Curcumin promotes health by diverse mechanisms. Scientists have documented curcumin’s anti-inflammatory, antioxidant, antimicrobial, neuroprotective, cancer-fighting, and immune-enhancing abilities.
  • Studies suggest that curcumin may help prevent or fight prostate, pancreatic, breast, and colon cancers.
  • Curcumin may help protect the brain against the devastating consequences of stroke and exposure to toxic heavy metals.
  • Individuals who consume more curcumin-rich curry are less likely to experience cognitive decline, suggesting curcumin could help protect the nervous system against aging. In laboratory and animal models, curcumin shows promise in preventing the pathological changes seen in the brains of Alzheimer’s disease sufferers.

POWERFUL NERVOUS SYSTEM PROTECTION

Among curcumin’s many benefits, protection from neurological damage ranks high on many researchers’ lists. “Curcumin has at least 10 known neuroprotective actions and many of these might be realized in [living subjects]…” wrote American scientists recently, in Advances in Experimental Medicine and Biology. “Dietary curcumin is a strong candidate,” they added, “for use in the prevention or treatment of major disabling age-related neurodegenerative diseases like Alzheimer’s, Parkinson’s, and stroke.”16

These scientists are not alone in their assessment of curcumin’s potential for protection against dreaded diseases such as Alzheimer’s. Numerous researchers are investigating curcumin’s protective activities in the brain. For example, Chinese scientists reported in early 2007 that curcumin protects the brains of laboratory animals from a type of injury that often follows stroke. Known as ischemia/reperfusion injury, this damage to brain tissue is believed to occur due to stroke-related deficits in the blood-brain barrier. A single injection of curcumin dramatically reduced ischemia-reperfusion damage, neurological deficits, and death, among animals with experimentally induced stroke.49

As another example, South African investigators wondered if curcumin could protect rats’ brains from lead poisoning.One way lead damages brain tissue is by inducing lipid peroxidation.50 Brain tissue is largely composed of lipids, so it’s especially vulnerable to this type of damage. By adding curcumin to test animals’ diets, lead toxicity was significantly reduced, possibly by raising concentrations of the antioxidant glutathione.51 Previously, Indian researchers reported that curcumin raised concentrations of glutathione and two potent antioxidant enzymes, superoxide dismutase and catalase, in the brains of lead-poisoned rats, significantly attenuating lead-induced damage.52

Other researchers report that curcumin may chelate, or bind to, toxic heavy metals, such as lead and cadmium, greatly reducing their toxicity to neurological tissues.53

Furthermore, scientists have reported that curcumin protects brain tissue against oxidative stress by promoting production of a protective enzyme, heme oxygenase-1 (HO-1). “In the *central nervous system+,” wrote the researchers, “HO-1 has been reported to operate as a fundamental defensive mechanism for neurons exposed to an oxidant challenge.”54 Traumatic injury to the brain also results in oxidative stress, often affecting cognition and “synaptic plasticity,” which is believed to play a crucial role in healthy learning and memory. In animal experiments, US researchers showed, “Supplementation of curcumin in the diet dramatically reduced oxidative damage and… counteracted the cognitive impairment caused by *traumatic brain injury+.”55

Cognitive Decline & Dementia

Even in the absence of injury or toxicity, loss of cognitive function is a hallmark of aging. Memory loss is believed to begin by age 50, and, by age 80, it’s predicted that nearly half of all individuals will advance to some form of dementia.56 Wondering if curcumin might protect aging brains from cognitive decline, Asian scientists conducted an epidemiological study of curry consumption and cognitive function among the elderly. They found that men and women who consumed turmeric-laced curry “occasionally,” “often,” or “very often,” had significantly better scores on a standardized test of mental status than subjects who “never or rarely” consumed curry. The investigators described these findings as “tentative evidence of better cognitive performance from curry consumption in nondemented elderly Asians…”25

ALZHEIMER’S DISEASE PROTECTION

Curcumin may offer protection against the most common cause of dementia: Alzheimer’s disease. Alzheimer’s disease is characterized by the accumulation of a malformed protein, amyloid-beta. Ordinarily, immune cells known as macrophages identify these defective proteins, engulf them, and destroy them. But for reasons that are not entirely clear, macrophages fail to perform this crucial function in Alzheimer’s disease.57 Using animal models of Alzheimer’s, scientists have shown that curcumin can enhance clearance of amyloid-beta, while reducing fibrils, which are also associated with Alzheimer’s pathology. Curcumin’s ability to cross the blood-brain barrier and directly bind to plaques may be important in its anti-amyloid activity.58

Los Angeles-based researchers tested the anti-amyloid activity of human macrophages taken from Alzheimer’s disease patients. After incubation with curcumin in the laboratory, uptake of amyloid-beta by macrophages from half of the patients significantly increased. The researchers concluded that this modification of the innate immune system by curcumin, “might be a safe approach to immune clearance of [abnormal amyloid-beta accumulation+ in Alzheimer’s disease brain.”59 These data appear to indicate that curcumin is protective against the development of Alzheimer’s disease, and that it may even help reverse the disease process, once begun.

SAFETY AND DOSING

Given that turmeric is a food that has been safely consumed for millennia, curcumin would appear to be the perfect dietary supplement.3 In fact, “Curcumin has an outstanding safety profile and a number of *multifunctional+ actions…” wrote US researchers recently.16 Phase I clinical trials, using massive doses of curcumin (up to 8 g/day for four months) in human volunteers, “did not result in discernible toxicities…”17

Of course, not everyone finds curry palatable, especially on a routine basis. But virtually anyone can swallow a simple daily supplement. Most commercial products provide 300-500 mg per pill, standardized to 95% curcumin. Reported adverse reactions have been limited to mild gastrointestinal distress, which may be minimized by consuming curcumin with food.60

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References

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2. Araujo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz. 2001 Jul;96(5):723-8.
3. No authors. Curcuma longa (turmeric). Monograph. Altern Med Rev. 2001 Sep;6 Suppl S62-6.
4. Limtrakul P. Curcumin as chemosensitizer. Adv Exp Med Biol. 2007;595:269-300.
5. Lin JK. Molecular targets of curcumin. Adv Exp Med Biol. 2007;595:227-43.
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7. Bright JJ. Curcumin and autoimmune disease. Adv Exp Med Biol. 2007;595:425-51.
8. Miriyala S, Panchatcharam M, Rengarajulu P. Cardioprotective effects of curcumin. Adv Exp Med Biol. 2007;595:359-77.
9. Thangapazham RL, Sharma A, Maheshwari RK. Beneficial role of curcumin in skin diseases. Adv Exp Med Biol. 2007;595:343-57.
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15. Funk JL, Oyarzo JN, Frye JB, et al. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod. 2006 Mar;69(3):351-5.
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23. Available at: http://rarediseases.info.nih.gov/html/reports/fy2004/niddk.html; http://rarediseases.info.nih.gov/html/reports/fy2001/orwh.html; http://rarediseases.info.nih.gov/html/reports/fy2000/nci.html. Accessed August 1, 2007.
24. Mosley CA, Liotta DC, Snyder JP. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103.
25. Ng TP, Chiam PC, Lee T, et al. Curry consumption and cognitive function in the elderly. Am J Epidemiol. 2006 Nov 1;164(9):898-906.
26. Lim GP, Chu T, Yang F, et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-7.
27. Li M, Zhang Z, Hill DL, Wang H, Zhang R. Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res. 2007 Mar 1;67(5):1988-96.
28. Singh S, Khar A. Biological effects of curcumin and its role in cancer chemoprevention and therapy. Anticancer Agents Med Chem. 2006 May;6(3):259-70.
29. Surh YJ, Chun KS. Cancer chemopreventive effects of curcumin. Adv Exp Med Biol. 2007;595:149-72.
30. Suryanarayana P, Krishnaswamy K, Reddy GB. Effect of curcumin on galactose-induced cataractogenesis in rats. Mol Vis. 2003 Jun 9;9:223-30.
31. Arun N, Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr. 2002;57(1):41-52.
32. Dujic J, Kippenberger S, Hoffmann S, et al. Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light. J Invest Dermatol. 2007 Aug;127(8):1992-2000.
33. Salvioli S, Sikora E, Cooper EL, Franceschi C. Curcumin in Cell Death Processes: A Challenge for CAM of Age-Related Pathologies. Evid Based Complement Alternat Med. 2007 Jun;4(2):181-90.
34. Bhattacharyya S, Mandal D, Sen GS, et al. Tumor-induced oxidative stress perturbs nuclear factor-kappaB activityaugmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcumin. Cancer Res. 2007 Jan 1;67(1):362- 70.
35. Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM. Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile. J Surg Res. 2000 Apr;89(2):169-75.
36. Pal S, Bhattacharyya S, Choudhuri T, et al. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detect Prev. 2005;29(5):470-8.
37. Perkins S, Verschoyle RD, Hill K, et al. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):535-40.
38. South EH, Exon JH, Hendrix K. Dietary curcumin enhances antibody response in rats. Immunopharmacol Immunotoxicol. 1997 Feb;19(1):105-19.
39. Kurup VP, Barrios CS, Raju R, et al. Immune response modulation by curcumin in a latex allergy model. Clin Mol Allergy. 2007;51.
40. Xu Y, Ku B, Tie L, et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res. 2006 Nov 29;1122(1):56-64.
41. Kim GY, Kim KH, Lee SH, et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol. 2005 Jun 15;174(12):8116-24.
42. Bhattacharyya S, Mandal D, Saha B, et al. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol Chem. 2007 Jun 1;282(22):15954-64.
43. Thangapazham RL, Sharma A, Maheshwari RK. Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J. 2006;8(3):E443-9.
44. Johnson JJ, Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 2007 Apr 18.
45. Hebert JR, Ghumare SS, Gupta PC. Stage at diagnosis and relative differences in breast and prostate cancer incidence in India: comparison with the United States. Asian Pac J Cancer Prev. 2006 Oct;7(4):547-55.
46. Kunnumakkara AB, Guha S, Krishnan S, et al. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaBregulated gene products. Cancer Res. 2007 Apr 15;67(8):3853-61.
47. Howells LM, Mitra A, Manson MM. Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines. Int J Cancer. 2007 Jul 1;121(1):175-83.
48. Poma P, Notarbartolo M, Labbozzetta M, et al. The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: Analysis of the possible molecular basis. Int J Mol Med. 2007 Sep;20(3):329-35.
49. Jiang J, Wang W, Sun YJ, et al. Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing bloodbrain barrier damage. Eur J Pharmacol. 2007 Apr 30;561(1-3):54-62.
50. Lidsky TI, Schneider JS. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain. 2003 Jan;126(Pt 1):5-19.
51. Dairam A, Limson JL, Watkins GM, Antunes E, Daya S. Curcuminoids, curcumin, and demethoxycurcumin reduce leadinduced memory deficits in male Wistar rats. J Agric Food Chem. 2007 Feb 7;55(3):1039-44.
52. Shukla PK, Khanna VK, Khan MY, Srimal RC. Protective effect of curcumin against lead neurotoxicity in rat. Hum Exp Toxicol. 2003 Dec;22(12):653-8.
53. Daniel S, Limson JL, Dairam A, Watkins GM, Daya S. Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorg Biochem. 2004 Feb;98(2):266-75.
54. Scapagnini G, Colombrita C, Amadio M, et al. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid Redox Signal. 2006 Mar;8(3-4):395-403.
55. Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol. 2006 Feb;197(2):309-17.
56. Braverman ER, Chen TJ, Prihoda TJ, et al. Plasma growth hormones, P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting: Evidence supported by structural equation modeling (SEM) parameter estimates. AGE. 2007; [Epub ahead of print].
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58. Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901.
59. Zhang L, Fiala M, Cashman J, et al. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer’s disease patients. J Alzheimers Dis. 2006 Sep;10(1):1-7.
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Success in Weight Loss Requires a Multi-faceted Approach

VISCERAL OR TRUNCAL fat is metabolically active fat. Excessive amounts of visceral fat is considered a crucial indicator for metabolic syndrome, and is also associated with cardiovascular disease, liver injury and increased risk of Type 2 diabetes. Early detection is essential for prevention of these diseases. Waist circumference (WC), fat mass, body mass index (BMI), body volume index, visceral fat area and waist-hip-ratio, all can predict visceral adiposity in abdominal obesity.

Waist circumference is found to be the best predictor of intra-abdominal fat thickness and central obesity. The absolute waist circumference (>102cm in men and >88cm in women) and the waist-hip ratio (circumference of the waist divided by that of the hips of >0.9 for men and >0.85 for women), are both used as measures of central obesity. For a given WC, the type of obesity can be determined by bioelectrical impedence and body volume index measurement. Visceral fat area (VFA) at the umbilicus level measured by CT is adopted as the gold standard, but it has many limitations. Recently, application of abdominal bioelectrical impedance analysis (BIA) for measuring VFA is widely used.

The measurement of ALT liver enzyme is associated with truncal/visceral fat accumulation, metabolic syndrome, raised BMI, hyperleptinemia, and hyperinsulinemia. This metabolically active fat induces non-alcoholic fatty liver disease with raised ALT levels. Obesity raises serum resistin levels, which in turn directly correlate to insulin resistance. Studies have also confirmed a direct correlation between resistin levels and Type 2 diabetes; and it is central obesity which seems to contribute to increasing levels of serum resistin. Serum resistin levels have been found to decrease with weight loss. Enzyme-linked immunosorbent assay (ELISA) tests detect circulating resistin protein levels. This is, therefore, a useful test to confirm metabolic syndrome.

Low Calorie
Diets

It has long been known that low calorie diets increase longevity and help prevent leading causes of death such as inflammatory diseases like cardiovascular disease and cancer. The mechanisms through which life extension occurs include improved mitochondrial functioning, activation of sirtuin genes (longevity genes), obesity reduction, and anti-inflammatory effects.

To keep in mind, though, being on a low calorie diet is not to become nutritionally compromised, or nutrient depleted or osteopenic or osteoporotic. Often, dietary supplementation may become necessary with low calorie diets. Of great help would be to make use of calorie restriction mimetics. These mimetics give one the same effects of decreased calorie intake without the need to starve oneself and don’t have the weight loss effects associated with low calorie intake, but do have the life extending effects comparable to those seen with low calorie intake. These mimetics switch off cancer genes, switch on longevity genes, and reduce inflammation and improve mitochondrial functioning, too.

Mimetics

While all diets don’t offer the secret to living life thinner, calorie restriction certainly has far-reaching benefits for longevity. This is where calorie restriction mimetics (CRM) come into play. There are a number of naturally occurring actors (from peptides and alkaloids to polyphenols and amino acids) that mimic the anti-aging effects of calorie restriction and show the same physiological effects. CRM can be described as a chemical compound or natural agent that can reproduce (or mimic) one or more principle biological effects of calorie restriction. There is a great deal of versatility in using CRM, as some may affect genetic controls of aging and others may be more specific to glucose metabolism, for example.

CRM isn’t a magic bullet in terms of weight loss. However, the longevity effects are far too considerable to be taken lightly. Speak to your healthcare practitioner about taking CRM supplements to induce long life, wellness and overall well-being.

CRM Protocol

  • Resveratrol (100mg twice daily)
  • Pterostilbene (50mg twice daily)
  • Carnosine (500mg twice daily)
  • Grape seed extract (100mg twice daily)
  • Alpha lipoic acid (R-forms) (150mg twice daily)
  • Acetyl-l-carnitine (500mg to 1,000mg twice daily)
  • Metformin (on prescription only) with vitamin B12 if insulin resistant
  • Good quality complete antioxidant formula

Success in Weight Loss
Requires a Multi-faceted
Approach

Cortisol Excess and Adrenal Fatigue
Elevated cortisol caused by stress or aging puts the body into a fat-storage mode. Adrenal stress causes cravings for coffee, soft drinks and sugar.

DHEA
DHEA (dehydroepiandrosterone) is an adrenal hormone that decreases in tandem with the aging process. DHEA opposes the fat-storage effects and cravings caused by elevated cortisol.
Rx Women: 0.5 to one tablet (12.5mg to 25mg) daily.
Rx Men: one to two tablets (25mg to 50mg) daily, as a single daily dose (after breakfast)

Herbal Adaptogens  
Herbal adaptogens contain adrenally-supportive herbal extracts (Rhodiola rosea and Ashwagandha). These stimulate the adrenals during low adrenal function  (adrenal fatigue), and calms adrenal function (and excessive cortisol release) during adrenal stress.

Insulin Resistance, Metabolic Syndrome and PCOS

Insulin resistance is a common cause of weight gain and PCOS, and makes weight loss difficult.

D-Chiro-Inositol 

  • D-Chiro-Inositol is an insulin-sensitising nutrient that improves the body’s responsiveness to insulin.
  • Rx: one capsule daily or twice daily, after meals

Other nutrients to aid with insulin resistance include: 

  • Irvingia Plus Fat Burner: one capsule twice daily, 20 minutes before meals
  • HCA and chromium: one to two caplets, 20 minutes before each meal (with chromium for decreasing insulin  resistance)
  • Alpha Lipoic Acid: one capsule twice daily
  • 7-Keto DHEA: 25mg per day
  • Krill Oil OR Fish Oil Extract Omega 3: two capsules daily
  • Vitamin D3: typically doses of 2000iu per day depending on vitamin D levels

Leptin

Leptin resistance has a lot in common with insulin resistance. Adipocytes (fat cells) are the primary cells for fat storage. Leptin is released by adipocytes to perform two critical functions. First, it signals the brain that enough food has been ingested and shuts down appetite. It then seems to initiate a process whereby the stored triglycerides (the form that most fat exists in the body) in the adipocytes are broken down into fatty acids that can be used for energy production.

The size and number of adipocytes increase with weight gain. They then release more and more leptin into circulation in an attempt to tell the brain that fat stores are adequate, and appetite needs to be controlled. However, because these same fat cells are now constantly surrounded by elevated levels of leptin, they progressively lose sensitivity for this leptin that they are producing in excess. Inadequate sensitivity results in reduced responsiveness, with two outcomes: first, normal fatty acid oxidation (fat burning) within the adipocyte is significantly reduced, and second, the adipocyte becomes less likely to absorb free fatty acids from circulation. This resulting excess of fatty acids floating in the bloodstream causes a functional insulin resistance in tissues.

Cortisol Excess and Adrenal Fatigue
Elevated cortisol caused by stress or aging puts the body into a fat-storage mode. Adrenal stress causes cravings for coffee, soft drinks and sugar.

DHEA
DHEA (dehydroepiandrosterone) is an adrenal hormone that decreases in tandem with the aging process. DHEA opposes the fat-storage effects and cravings caused by elevated cortisol.
Rx Women: 0.5 to one tablet (12.5mg to 25mg) daily.
Rx Men: one to two tablets (25mg to 50mg) daily, as a single daily dose (after breakfast)

Herbal Adaptogens  
Herbal adaptogens contain adrenally-supportive herbal extracts (Rhodiola rosea and Ashwagandha). These stimulate the adrenals during low adrenal function  (adrenal fatigue), and calms adrenal function (and excessive cortisol release) during adrenal stress.

Insulin Resistance, Metabolic Syndrome and PCOS

Insulin resistance is a common cause of weight gain and PCOS, and makes weight loss difficult.

D-Chiro-Inositol 

  • D-Chiro-Inositol is an insulin-sensitising nutrient that improves the body’s responsiveness to insulin.
  • Rx: one capsule daily or twice daily, after meals

Other nutrients to aid with insulin resistance include: 

  • Irvingia Plus Fat Burner: one capsule twice daily, 20 minutes before meals
  • HCA and chromium: one to two caplets, 20 minutes before each meal (with chromium for decreasing insulin  resistance)
  • Alpha Lipoic Acid: one capsule twice daily
  • 7-Keto DHEA: 25mg per day
  • Krill Oil OR Fish Oil Extract Omega 3: two capsules daily
  • Vitamin D3: typically doses of 2000iu per day depending on vitamin D levels

Leptin

Leptin resistance has a lot in common with insulin resistance. Adipocytes (fat cells) are the primary cells for fat storage. Leptin is released by adipocytes to perform two critical functions. First, it signals the brain that enough food has been ingested and shuts down appetite. It then seems to initiate a process whereby the stored triglycerides (the form that most fat exists in the body) in the adipocytes are broken down into fatty acids that can be used for energy production.

The size and number of adipocytes increase with weight gain. They then release more and more leptin into circulation in an attempt to tell the brain that fat stores are adequate, and appetite needs to be controlled. However, because these same fat cells are now constantly surrounded by elevated levels of leptin, they progressively lose sensitivity for this leptin that they are producing in excess. Inadequate sensitivity results in reduced responsiveness, with two outcomes: first, normal fatty acid oxidation (fat burning) within the adipocyte is significantly reduced, and second, the adipocyte becomes less likely to absorb free fatty acids from circulation. This resulting excess of fatty acids floating in the bloodstream causes a functional insulin resistance in tissues.

Consistent overeating confuses the efficient transmission of messages, causing a breakdown that leads to weight gain,

and additional consequences such as heart disease. Fat used to be viewed only as a storage place in the body for extra calories. However, we now know that it’s actually an endocrine organ.

Eating habits can cause havoc in the body’s communication system that dictates metabolism and appetite. Consistent overeating confuses the efficient transmission of messages, causing a breakdown that leads to weight gain, and additional consequences such as heart disease. Fat used to be viewed only as a storage place in the body for extra calories. However, we now know that it’s actually an endocrine organ. The fat that we moan and groan about when it accumulates on our thighs, buttocks and abdomen could ironically keep us lean. This white adipose tissue secretes the hormone leptin, which informs the brain about our levels of fat, telling us when to eat and when to stop eating.

Leptin is normally secreted in a circadian rhythm, with as many as 32 pulses of activity occurring over a 24-hour period. The highest levels are found during the first few hours of sleep, decreasing to the lowest in the morning. In obese people, the change in blood leptin levels is less significant than in lean people. One of the reasons for this is that an excess consumption of food has a negative impact on leptin’s ability to communicate adequately with the brain. This results in insulin, thyroid, epinephrine and leptin resistance, and potential weight gain.

If there’s leptin resistance, the brain doesn’t register signals to reduce appetite, leaving a person feeling constantly hungry. Normally, when you’ve eaten sufficiently, the brain receives a signal that leptin levels are high, and it increases metabolism and decreases appetite. Conversely, when your body needs food, the brain tells you to eat. When this process is inhibited by bad eating habits, your brain doesn’t know to tell you when to stop and excess calories are sent to storage as fat. Increased levels of triglyceride (a type of fat found in your blood) caused by overeating, have been linked to leptin resistance. This fat decreases the transport of leptin across the blood brain barrier, preventing leptin from entering the brain.

Leptin inhibits insulin secretion in the pancreas, and when your body is resistant to leptin, the pancreas isn’t able to sense it and keeps making insulin, leading to an excess and the possibility of insulin resistance – another cause of weight gain.

Yet another cause of leptin-resistant weight gain is tied in with epinephrine, a hormone and a neurotransmitter that is a prime factor in the body’s fight or flight response, increasing heart rate, constricting blood vessels and dilating air passages when the body senses danger. Epinephrine has short-term control of leptin and when the body’s sympathetic nervous system is activated in quick bursts during moments of panic, leptin production is depressed. The brain uses epinephrine to stimulate metabolism in fat cells and if the brain is repeatedly attempting to use this hormone to no effect, unusually high levels can occur, and fat cells eventually become immune to it. This resistance leads to weight gain, specifically in the abdominal area, which is most often associated with reproductive organ cancer and heart disease.

A resistance to leptin produces “false starvation”, slowing thyroid function even in overweight people. Leptin and thyroid resistance restrict the natural heat production in the body, so fat and calories aren’t efficiently burned away.

To ensure the body’s optimal functionality, it’s important to listen to the brain’s messages. However, if our bad habits inhibit the brain’s ability to communicate effectively, we can get stuck in a rut of silent rebellion. A lifestyle change, specifically in terms of eating habits, as well as supplementation, will greatly assist in getting your body back in line. While a diet high in carbohydrates and saturated fats is a definite no-no if you are leptin resistant, a “high good fat” diet has shown successful results. Stock your pantry (and plate) with monosaturated fats like olive oil, canola oil, avocados, nuts and seeds, olives and dark chocolate, and listen up for leptin’s long-forgotten call.

Protocol for Decreasing
Leptin Resistance

Irvingia Gabonensis is a herb showing remarkable success as a viable form of leptin resistance treatment. This herb also lowers cholesterol levels as well as fasting glucose levels. It also reduces the C-reactive protein that binds leptin and makes one resistant to it. Using this herb alone can help correct leptin resistance. Resveratrol and green tea extracts such as EGCG are also useful.

Neurotransmitters and Weight Loss

Low levels of brain serotonin are commonly associated with food cravings.

5-HTP 

  • 5-hydroxy-tryptophan (an amino acid) is the direct precursor of serotonin. Unlike SSRIs, which are serotonin re-uptake inhibitors, and can cause weight gain, serotonin precursors, such as 5-HTP, reduce appetite and cause weight loss.
  • Rx: one to two capsules (100mg to 200mg) twice daily, on an empty stomach

Fiber Intake and Weight Loss
An adequate intake of fiber is important for weight loss because it lowers the glycemic index (GI) of meals and promotes a feeling of fullness.

Inflammation, Liver Detoxification and Weight Loss
Fat is metabolised under the control of a hormone called leptin. Sub-clinical inflammation causes the release of leptin-desensitising inflammatory molecules such as C-reactive protein (CRP). When leptin sensitivity is reduced, weight loss becomes more difficult. Furthermore, any weight loss program places an increased toxic burden on the liver, due to metabolised fat releasing accumulated stored toxins into the blood stream. Supporting Phase 2 liver metabolism, to flush out circulating toxins, is an important part of any weight loss program.

An adequate intake of fiber  is important for weight loss because it lowers the glycemic index (GI) of meals and promotes a feeling of fullness. 

  • Curcumin: Curcumin is extracted from turmeric spice. It reduces CRP and other inflammatory markers. Curcumin also supports Phase 2 liver detoxification with piperine for enhanced absorption.
  • Silibinin: milkthistle extract is extremely useful in detoxifying the liver and helping with blood glucose and cholesterol management.

Sleep, Melatonin and
Weight Loss

Studies show that lack of sleep is associated with weight gain, insulin resistance and elevated cortisol. Elevation of yet another hormone called ghrelin also leads to weight gain with sleep deprivation.

Melatonin and Melatonin Slow Release 

  • Melatonin is responsible for healthy sleep architecture. It exhibits no addictive or tolerance-inducing properties. It is vailable in standard formulation for patients exhibiting difficulty falling asleep, and in slow release form, for patients who can’t maintain sleep.
  • Rx: one tablet (3mg) at bedtime

Additional Weight Loss Nutraceuticals

CLA (Conjugated Linoleic Acid) 

CLA is a naturally occurring fatty acid. Clinical trials have shown that usage promotes weight loss (2000mg twice daily after food).

L-Carnitine
Studies show that L-carnitine (an amino acid) aids in weight loss by converting stored body fat into energy. Taking 1400mg of L-carnitine twice daily, with or without food, may assist with weight loss.

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References:

  • Hursting SD, Lavigne JA, et al. Calorie restriction, aging and cancer prevention: mechanisms of action and applicability to humans. Ann Rev Med. 2003;54:131-152
  • Holt S Specific anti-aging factors for natural clinicians. Townsend Letter Jul 2008:90-6
  • Tsai AG, Wadden TA. Systematic review: an evaluation of major commercial weight loss programs in the United States. Ann Intern Med 2005;142:56
  • Melanson E, Astrup A, Donahoo W. The Relationship between Dietary Fat and Fatty Acid Intake and Body Weight, Diabetes, and the Metabolic Syndrome. Ann Nutr Metab 2009;55:229-243
  • Stern L, Iqbal N, Seshadri P, et al: The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med 2004;140:778
  • Skov AR, Toubro S, Bulow J, et al: Changes in renal function during weight loss induced by high vs low-protein low-fat diets in overweight subjects. Int J Obes Relat Metab Disord 1999;23:1170
  • Votruba SB, Horvitz MA, Schoeller DA: The role of exercise in the treatment of obesity. Nutrition. 2000;16:179
  • Trayburn P, Beattie J. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc. 2001;60:329-39
  • http://journals.cambridge.org/action/displayAbstract?fromPage =online&aid=804764
  • Radi R, Nikolić V, et al. Circadian rhythm of blood leptin level in obese and non-obese people. Coll Antropol. 2003;27:555-61
  • http://www.ncbi.nlm.nih.gov/pubmed/14746143
  • Kalra S. Central leptin insufficiency syndrome: An interactive etiology for obesity, metabolic and neural diseases and
  • for designing new therapeutic interventions. Peptides. Jan 2008;29(1):127-38
  • http://www.sciencedirect.com/science/article/pii/S0196978107004305
  • Banks W, Coon A, et al. Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes. 2004;53:1253-60
  • http://diabetes.diabetesjournals.org/content/53/5/1253.short
  • Seufert J. Leptin effects on pancreatic beta-cell gene expression and function. Diabetes. 2004;53(1):152-8
  • http://diabetes.diabetesjournals.org/content/53/suppl_1/S152.short
  • Zhang C, Rexrode K, et al. Abdominal Obesity and the Risk of All-Cause, Cardiovascular, and Cancer Mortality. Sixteen Years of Follow-Up in US Women. Circulation. 2008;117:1658-67
  • http://circ.ahajournals.org/content/117/13/1658.abstract
  • Huo L, Munzberg H, et al. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin. Endocrinology. 2004;145:2516-23
  • http://endo.endojournals.org/content/145/5/2516.short
  • Wiegle D, Cummings D, et al. Roles of Leptin and Ghrelin in the Loss of Body Weight Caused by Low Fat, High Carbohydrate Diet. The Journal of Clinical Endocrinology & Metabolism. Apr 2003;88(4):1577-86
  • http://jcem.endojournals.org/content/88/4/1577.short

Amazing Health Benefits of Spirulina and Chlorella

Amazing Health Benefits of Spirulina and Chlorella

Microalgae supplements containing spirulina and chlorella are very cost effective,  and are in fact, one of the best investments you can make in your economic and health future, because by consuming superfood supplements in the form of spirulina, chlorella blue-green algae, you can prevent many chronic diseases and metabolic disorders and thereby dramatically reduce the amount of dollars you’ll spend on healthcare costs and lost productivity down the road. In this sense, I’ve always said that supergreens and superfood supplements were free of charge — they actually pay you back, because they give you longer life, higher productivity, more energy, plus the opportunity to avoid high-priced prescription drugs, doctor visits, surgical procedures, and other useless procedures promoted by organized medicine.

From aluminium in deodorant to mercury in dental fillings, metal toxicity comes at us from every angle these days. The presence of these heavy metals (and others such as arsenic, cadmium and lead) has increased as industrialization and its waste products spread. We can work to avoid these substances as much as possible, but some exposure will still occur at times. Since even small amounts of heavy metals in the body can cause negative side effects like fatigue, headaches, digestive problems and skin conditions, it’s important to use natural methods to cleanse your body of these toxins.

Why Spirulina and Chlorella Are Effective for Heavy Metal Detox

The answer to natural heavy metal detoxification is as simple as a single-celled organism. Spirulina and chlorella are two separate micro-algae organisms which have existed on earth since the dawn of time. Both were revered as powerful superfoods in many traditional societies, and today are more relevant than ever for achieving overall health and well-being.

Spirulina has been shown as an effective chelating agent for removing toxins such as mercury, and radioactive substances from the body. It has also been used to remove cadmium and lead from waste water.

While some detoxifying supplements simply release toxins from cells and tissues, chlorella is particularly adept at binding to toxic metals and ushering them out of the entire system. Chlorella contains proteins and peptides which are designed to bind to these substances and carry them out of the body. The chlorophyll in chlorella also aids heavy metal detoxification.

Other Amazing Health
Benefits

Just as important as their ability to detox heavy metals, both spirulina and chlorella exhibit strong healing and regenerating capabilities. They are filled with beneficial vitamins, minerals, proteins and fats which work together in a synergistic way to provide energy and vitality.

Appropriate Dosage

Spirulina and chlorella can be used in very high doses for heavy metal detox. Because they are so effective at binding toxins and purging them from the body, they can actually reduce some of the common side effects associated with detoxification. A typical dosage of spirulina or chlorella for heavy metal detox is about 20 – 30 grams per day. They can be used together if desired. You may want to start with as little as 500mg daily and work up as needed to allow your body to adjust. After completing detox, you can taper down to a maintenance dosage of 3 – 6 grams per day.

It’s important to find a manufacturer of spirulina or chlorella who takes the proper steps to ensure a clean and digestible product free from fillers and additives. A little research can reveal which manufacturers are the most reputable.  (For further reading visit www.naturalnews.com)

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5 Immune-Boosting Benefits of Turkey Tail Mushroom

Medicinal Mushrooms are well known for their potent medicinal qualities. All medicinal mushrooms are effective at supporting immune health if they:

1. Are hot water extracts and 

2. contain effective levels of beta glucans

  • Beta glucans (non-linear polysaccharides) are structurally unique and have potent immune stimulating properties
  • β-glucans are known as “biological response modifiers” because of their ability to activate the immune system.
  • β-glucans seem to make the immune system work better without becoming overactive
  • Immunologists at the University of Louisville, discovered that a receptor on the surface of innate immune cells called Complement Receptor 3 (CR3 or CD11b/CD18) is responsible for binding to beta-glucans, allowing the immune cells to recognize them as “non-self.”

While there is an abundance of mushrooms with medicinal properties, one of the most well-known is Trametes versicolor, also known as Coriolus versicolor.

Commonly called turkey tail due to its striking colors, Trametes versicolor has been used around the world for centuries to treat various conditions. Perhaps the most impressive quality of the turkey tail mushroom is its ability to enhance the health of your immune system. Here are 5 immune-boosting benefits of the turkey tail mushroom.    (Info below summarized obtained from article written by Jillian Kubala, MS, RD)

5 Immune-Boosting Benefits of Turkey Tail Mushroom

1. Rich in antioxidants

Oxidative stress results from an imbalance between antioxidants and unstable molecules known as free radicals. This can result in cellular damage and chronic inflammation. This imbalance has also been linked to an increased risk of developing health conditions, for example cancer and heart disease. disease.

Turkey tail contains a wide variety of phenol and flavonoid antioxidants which help promote your immune system health by reducing inflammation and stimulating the release of protective compounds.

2. Contains
Immune-Boosting
Polysaccharopeptides

Polysaccharopeptides are protein-bound polysaccharides (carbohydrates) that are found in, for example, turkey tail mushroom extract. Krestin (PSK) and Polysaccharide Peptide (PSP) are two types of polysaccharopeptides found in turkey tails.

PSK stimulates dendritic cells that promote immunity to toxins and regulate the immune response. In addition, PSK activates specialized white blood cells called macrophages, which protect your body against harmful substances like certain bacteria.

3. May Improve Immune Function in People With Certain Cancers

Research has demonstrated that turkey tail mushrooms may have antitumor properties, thought to be related to its immune-boosting effects.
One test-tube study found that PSK, the polysaccharopeptide found in turkey tail mushrooms, inhibited the growth and spread of human colon cancer cells (.

What’s more, a certain type of polysaccharide found in turkey tail mushrooms called Coriolus versicolor glucan (CVG) may suppress certain tumors.
Researchers attributed this development to enhanced immune response.

4. May Enhance the
Efficacy of Certain
Cancer Treatments

Several research studies have demonstrated that turkey tail mushroom enhances the efficacy of both chemotherapy and radiation in people with certain cancers.

5. May Enhance Gut Health

Keeping a healthy balance of beneficial bacteria in your gut is critical for maintaining a strong immune system. Your gut bacteria interact with immune cells and directly impact your immune response
Turkey tail contains prebiotics, which help nourish these helpful bacteria.

Turkey tail mushroom may positively impact gut bacterial balance by enhancing the growth of beneficial bacteria while suppressing harmful species.

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Vibrational Medicine Is The Future Of Medicine

Vibrational Medicine Is The Future Of Medicine

Info obtained from naturalnews.com
HUGE credit to Mike Adams and naturalnews.com for ongoing research

Vibrational medicine is a promising area of “technology” (it’s difficult to call it that) that covers a variety of pioneering healing modalities now known to be far more powerful than drugs and surgery in improving the lives of patients. These modalities include:

  • Phototherapy: harnessing the healing power of natural sunlight to prevent cancer, reverse clinical depression, alter moods, increase bone density and much more.
  • Color therapy: using selected wavelengths of natural sunlight to create a physiological, psychological or energetic response in a patient.
  • Homeopathy: using the “memory of water” to imprint a patient with the healing properties of selected substances.
  • Sound therapy: the therapeutic use of sound waves to create a healing response in the patient. Music therapy is one branch of sound therapy.
  • Spiritual healing: harnessing the power of prayer and focused intention to alter the health outcome for a patient. Also called “non-local medicine.” It is well supported by double-blind placebo studies.
  • Mind/body medicine: harnessing the power of the patient’s own mind to affect healing. This is typically accomplished through meditation exercises, laughter as medicine, or creative visualization exercises. The proven power of the placebo effect demonstrates the enormous healing potential of this modality (in tens of thousands of medical studies, the placebo effect has been proven more effective than any prescription drug known to mankind).
  • Acupuncture: the use of tiny needles to alter the flow of chi (energy) through the body for a specific health reason.
  • Magnetic therapy: the use of permanent magnets or electromagnets to catalyze a healing response in the patient. Some magnetic therapies attempt to augment the Earth’s magnetic field; others deliver high-energy magnetic bursts in an attempt to destroy cancer tumors.
  • Crystals, gems and rocks: the harnessing of vibrations from crystals and other rocks for healing purposes. All crystals vibrate. In fact, if you are reading this report, you’re using crystal vibration right now! (The CPU clock in your computer operates on a timing signal generated by a crystal.)
  • Electromedicine: applying small electrical currents to selected points on the body to accelerate healing, repair broken bones, create changes in muscle training and body tension, destroy invading bacteria, and other uses. The body already relies on electromedicine for internal healing. All bones, for example, are piezo-electric devices that create an electric charge when stressed, attracting minerals like calcium to the site of the charge. In addition, a continuous electric current, when applied to the skin over a blood vessel, kills bacteria present in the blood. Electromedicine has great potential for healing.

There are many other areas as well, but these represent some of the most popular vibrational medicine technologies being used today.

Unlike the other technologies mentioned in this report, much of the technology already exists for vibrational medicine. Every therapy mentioned above is being used right now in the United States and around the world. The challenge is to see their use become widespread and accepted by practitioners of western medicine. Unfortunately, most practitioners of modern (western) medicine are steeped in an outdated mindset of drugs and surgery and tend to shun any therapy that isn’t sanctioned by the pharmaceutical industry.

Let’s take a closer look at the kind of paradigm shifts that will be required in modern medicine in order for vibrational medicine to earn increased credibility.

A brief history of
western medicine

Looking at the history of western medicine, the modalities and belief systems are readily divided into three chronological phases:

  1. Physical medicine.
  2. Chemical medicine.
  3. Energetic medicine.

Physical medicine describes the sort of medicine practiced by the western world in the 19th early 20th centuries. If a foot became infected, the doctor cut it off. Surgery was regarded as a “heroic” procedure (to a very large degree, it still is), and disease was understood to be caused by the physical malfunctioning of physical organs.

Chemical medicine emerged in response to the discovery of penicillin and the realization that certain chemicals — prescription drugs or antibiotics — could target and destroy infectious disease. This belief continues to this day, where diseases are now commonly described as “chemical imbalances” that must be treated with a lifetime of prescription drugs. Today, western medicine is firmly seated in the belief system of chemical medicine. Pharmaceutical companies, which dominate today’s medical landscape, rely exclusively on this paradigm to market their products and convince patients they need potent chemicals in order to be happy, healthy or sane. This is why nearly all diseases and symptoms are presently described as chemical imbalances that can be corrected with expensive drugs. This belief is a distortion, however.

Energetic medicine (vibrational medicine) is just starting to be explored by the medical mainstream. In energetic medicine, the powerful effects of subtle energy systems are explored and leveraged for healing. Energetic medicine recognizes the whole of the patient rather than the parts (as in physical medicine). Energetic medicine also believes that the human body is not a chemical dumping ground, and that both disease and health have core underlying causes that go far deeper than mere symptoms.

The future of medicine
is vibrational

Tomorrow’s medicine will no doubt increasingly rely on vibrational medicine. Not only is it a more advanced perspective on the true causes of disease and health, but it can be offered to patients with virtually no side effects and at very low cost. As one simple example, if a doctor can help a patient laugh heartily for five minutes, the patient will be significantly helped in all three areas: physical, chemical and vibrational.

From a physical point of view, the very act of laughing moves lymph fluid, promotes the oxygenation of body cells and organs, and improves circulation. From a chemical point of view, laughter results in the creation of literally tens of thousands of dollars worth of healthful brain chemicals (if you had to buy them, that is) that improve mood, enhance alertness, etc. From an energetic point of view, laughter helps relax the patient’s body and mind, opens them to enjoying interaction with others, and literally restructures their internal energies. That’s just one reason why Dr. Patch Adams, popularized in the movie with Robin Williams, relied so heavily on laughter as a powerful healing tool. In a very real way, laughter is perhaps one of the most powerful healing tools available to mankind, and yet today’s hospitals and doctors’ offices are hardly places that inspire unbridled joy.

The power of placebo

Interestingly, vibrational medicine has already been proven by literally tens of thousands of clinical studies to be the single most powerful healing tool known to western medicine, and yet it remains largely ignored by the very same people conducting the studies. Let me explain: in most clinical trials, there is something called the placebo effect which describes the level of healing that takes place in patients who were given no drugs and no surgery but who thought they received the drugs or surgery. For example, they would be given inert pills or subjected to a “sham surgery” that actually resulted in no real surgical operation. This is standard practice in clinical trials.

But even though the patients don’t receive the drugs or surgery as part of the study, they routinely show permanent improvements in their health. One study of Parkinson’s patients proved that this genuine health improvement remained strong even twelve months after the placebo surgery, and the measure of improvement was objective: even the medical staff agreed that patients showed measurable improvements.

Obviously, if patients are getting better thanks to the placebo effect, it can’t be the drugs or surgery that’s causing the improvement. The healing effect is caused by the mind of the patient. Their belief in the drug or surgery is what’s causing them to get better, not the actual drug or surgery (since they didn’t receive either).

Now here’s the amazing part: if you take a closer look at these tens of thousands of studies, you’ll find that the placebo effect has been proven effective in treating approximately 30% of all disorders and diseases. That’s right: this single mind/body tool has been scientifically proven to reverse or improve 30% of all diseases and symptoms: heart disease, stroke, arthritis, cancer… you name it. The proof is right there in the studies.

This is astonishing: mind/body medicine offers us a powerful healing tool that works with no negative side effects and zero cost… and it’s effective against practically any disease or condition. So what does western medicine do with this knowledge? They discard it. The placebo effect is routinely tossed or ignored. It’s considered a “false” result by medical researchers, even when the numbers prove it to be not just real, but perhaps the most powerful healing tool of all.

Truth is whatever
agrees with your
beliefs

Why does this happen? Doctors, researchers, surgeons and others in the medical community function like everyone else: when presented with evidence that contradicts their firmly held belief systems, they discard the new evidence because it doesn’t fit their internal model of the way the world works. Accordingly, the mountain of evidence supporting the placebo effect gets routinely discarded not because it isn’t compelling and scientific, but because modern medicine doesn’t understand how it could work. It doesn’t fit the model.

And it’s not just the placebo effect that gets ignored. Homeopathy is also routinely ignored or even attacked by western medicine for the simple reason that western medical technology doesn’t understand how it works, either. In a homeopathic remedy, an extract from a particular element such as a flower, a plant, or even a poison like arsenic, is mixed with water and then diluted to such extremes that there’s not a single molecule of the original element remaining in the final mixture. Yet the final mixture holds the “memory” or the “vibration” of the original element that was used, and it exhibits scientifically measurable and verifiable effects on biological systems (both humans and animals) when consumed.

The evidence showing that homeopathic remedies work is not merely compelling, it is scientifically robust. An honest researcher reviewing the clinical evidence on homeopathy can only reach one of two conclusions: either homeopathy works, or controlled, double-blind placebo clinical trials don’t work. In other words, if you measure the effect of homeopathic remedies using the same science and scrutiny as clinical drug trials, you get a significant result that proves homeopathic remedies work. And yet western medicine continues to throw out this scientific reality, not because it hasn’t been scientifically proven, but because it doesn’t fit the model.

Homeopathy is one of the most promising areas of vibrational medicine. Homeopathic remedies can help people fight infectious disease, reverse cancer and diabetes, improve their brain function, detoxify their systems, recover from wounds more quickly, increase fertility, and accomplish a long list of other health benefits.

Phototherapy

Phototherapy represents a rapidly emerging branch of vibrational medicine, and it’s being slowly accepted by the scientific community. In experiments with infrared light, NASA (National Aeronautics and Space Administration) has shown that flesh wounds like scrapes, cuts and burns, heal 40% faster when exposed to a few minutes of infrared LED light each day. The mere presence of the light causes the body to accelerate its healing.

Light is a powerful healing tool, and no light is more available than our own sun. The sun is a source of tremendous healing potential. With natural sunlight, people can reverse prostate cancer and breast cancer, reverse clinical depression, enhance their bone density and prevent osteoporosis, vastly improve circulation, accelerate wound healing, and experience a long list of other significant health benefits. And yet, remarkably, nearly the entire population of the western world has been taught to believe that sunlight is dangerous.

People are warned to “stay out of the sun!” They slather on sunscreen, they wear heavy clothing, and they avoid the sun at all costs. Meanwhile, rates of prostate cancer are skyrocketing and vitamin D deficiency is now one of the most common nutritional deficiencies in America, Canada and Europe. With daily exposure to natural sunlight, the body creates its own vitamin D and puts it to work preventing prostate cancer, breast cancer and a long list of other disorders.

People need natural sunlight. It seems so obvious that it’s almost ridiculous having to point it out. And yet fear of the sun is so deeply ingrained in western societies that merely mentioning the phrase, “sunlight is good for you…” earns you gaping stares from practically everyone. Clearly, the human species didn’t evolve under fluorescent lighting: it evolved under the natural sun, and as human beings, we depend on frequent exposure to the sun for optimum health. Without sunlight, in fact, we cannot function in a healthy way. The growing problem of Seasonal Affective Disorder, where people experience deep depression due to lack of sunlight, is just one of the many clues pointing to the reality that people need natural sunlight in order to be healthy.

Lack of sunlight is even part of the reason we’re seeing an epidemic of obesity: sunlight exposure diminishes cravings for carbohydrates and sweets by balancing levels of serotonin in the brain.

Surgical
Sound Waves

Another promising area of vibrational medicine involves the use of sound waves for manipulating both physical tissues and energetic fields in the body. For this discussion, I’ll stick with the physical tissues.

By using standing waves of low frequency sound combined with subtle variations in the frequency and wavelength, we can directly control fluids (like blood and lymph) and even manipulate tissues in the human body without needing invasive surgery. How?

Cymatics =
the study of sound on
physical matter
Sound Waves

Sound restructures physical matter. This is evidenced by observing the effect of sound waves on grains of sand spread across the top of a large drum. If you hum into the drum, the sand will form physical patterns that coalesce across the drum head according to slight variations in pitch and amplitude. The science is called cymatics, and much of the original work in this area was conducted by the late Hans Jenny. (See http://www.cymaticsource.com for information.)

In cymatics, we see that sound creates waves of force that can move physical objects either towards or away from the source of that sound. In my own experiments using tone generator software, home speakers, sheet metal, and dirt from my back yard (how’s that for high-tech?), I was able to propagate grains of dirt and sand along a radiating path from the source of the sound by simply altering the frequency of the sound. (You have to watch the amplitude, however, because if the sound waves are too strong, the grains of sand will leap right off the sheet metal.)

For example, if you start with a sound frequency of 300 hertz (300 cycles per second), and then slowly reduce the frequency (pitch down the sound), it will elongate the wavelength of the sound and the grains of sand will slowly move away from you. If you start at a low frequency and increase the pitch, the grains of sand will move towards you as if on a conveyer belt.

“”Such technology blends the often mysterious world of vibrational medicine with today’s so-called “hard core science” to bring significant new healing modalities to the world of medicine. If sound can be widely accepted as a healing technology by organized medicine, further exploration into phototherapy, homeopathy and acupuncture is likely to follow. And that’s how modern medicine graduates from a stage two (chemical medicine) paradigm and moves into stage three (vibrational medicine).”” Naturalnews.com

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Wrap Up

“”In all, vibrational medicine represents the next phase in the evolution of healing technology. It delivers powerful healing with no negative side effects and at very low cost. When fully embraced by the medical community, vibrational medicine will make chemicals and prescription drugs virtually obsolete. When it comes to vibrational medicine, the science is already here: reliable studies prove its efficacy. But what’s needed is the acceptance of this technology by the medical community, and that acceptance will take time to achieve.”” I quote Mike Adams and naturalnews.com

7 Ways Phosphatidylcholine Can Benefit Your Health!

7 Ways Phosphatidylcholine Can Benefit Your Health!

Phosphatidylcholine (PC) is a type of Phosphoglyceride Phospholipid. Here is the Biological Function and Health Benefits of Phosphatidylcholine:

Aging & Life Extension

The body’s endogenous Phosphatidylcholine levels decline in conjunction with the Aging Process and Phosphatidylcholine (especially when administered via intravenous infusion) may reverse the deterioration of Cell Membranes that ocurs in conjunction with the progression of the Aging Process. Phosphatidylcholine may possess Life Extension potential:

As the body’s Cell Membranes age, they contain less Phosphatidylcholine, and more Cholesterol and sphingomyelin causing them to become less fluid and more rigid.

Phosphatidylcholine 
& Your
Cardiovascular System:

PC (especially when administered via intravenous infusion) may improve the condition of Angina patients and helps to prevent and treat Atherosclerosis. Phosphatidylcholine helps to maintain the elasticity of Blood Vessels.

PC is essential for the formation of Cell Membranes and is essential for the structural and functional integrity of Cell Membranes. Supplemental Phosphatidylcholine enhances the function of Cell Membranes throughout the body and comprises approximately 65% of most Cell Membranes.  Phosphatidylcholine may help to prevent Colitis. Phosphatidylcholine is essential for the initial emulsification of dietary Fats (as a constituent of Bile) prior to their further digestion.

Phosphatidylcholine may prevent and dissolve Gallstones and Kidney Stones by emulsifying their constituent Lipids. Phosphatidylcholine inhibits the ability of Alcohol (ethanol) and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) to cause Gastric Ulcers.  Phosphatidylcholine may reduce Intestinal Permeability (it has been demonstrated to reduce bacterial translocation).  PC also inhibits the ability of Alcohol to damage the Pancreas ; PC inhibits the ability of Alcohol (ethanol) to cause Pancreatitis.

Phosphatidylcholine (especially delayed release form of Phosphatidylcholine – 6,000 mg per day) may alleviate Ulcerative Colitis.

PC may help prevent age-related hearing loss.

Phosphatidylcholine 
& Your
Metabolism

Phosphatidylcholine is essential for the correct metabolism of Cholesterol
Phosphatidylcholine helps to keep Cholesterol soluble ; may inhibit the absorption of dietary Cholesterol ; keeps Cholesterol isolated from the lining of Arteries ; prevents the oxidation of LDL Cholesterol ; is an essential component of High Density Lipoproteins (HDL) – it comprises 22% of HDL ; is an essential component of  Low Density Lipoproteins (LDL) ;

Phosphatidylcholine may help to prevent and treat Cirrhosis (including alcholic Cirrhosis).  Phosphatidylcholine may help to prevent and treat Fatty Liver.  Phosphatidylcholine is essential for the detoxification functions of the Liver.

The Polyunsaturated Fatty Acid form of Phosphatidylcholine (1,800 mg per day) may be beneficial for the treatment of most forms of Hepatitis.

Phosphatidylcholine 
& Your
Nervous System

Phosphatidylcholine may prevent Age Associated Memory Impairment ; Phosphatidylcholine may prevent the further deterioration of Mental Function in Alzheimer’s Disease patients ; improves Concentration and Memory in Dementia patients and may increase Acetylcholine levels in Dementia patients ; may improve mental performance in Down’s Syndrome patients; may improve Learning ability ; may improve Memory (especially in persons with existing Memory impairment and in those with diminished Acetylcholine levels).

Phosphatidylcholine nourishes Myelin Sheaths surrounding Neurons.
Neurons require large amounts of Phosphatidylcholine for their repair and maintenance. Phosphatidylcholine is also required for the growth of new Neurons.

Phosphatidylcholine 
& Your
Respiratory System

Phosphatidylcholine may alleviate some of the damage inflicted on Lung tissues by cigarette smoking

Phosphatidylcholine & Fertility

Phosphatidylcholine may alleviate Male Infertility – Phosphatidylcholine is a component of the Seminal Plasma component of Semen

Phosphatidylcholine & Skin

Phosphatidylcholine controls the transfer of endogenous chemicals into Skin Cells and may improve the visual appearance of dull Skin.

Maximum Dosage

Usually we use 500mg 2-4tablets / day in therapy.
The maxium safe dosage for Phosphatidylcholine is 30,000 mg (30 grams) per day !

Bioavailability

Orally-administered Phosphatidylcholine is very well absorbed. Up to 90% is absorbed when it is consumed with meals. Oral doses of Phosphatidylcholine result in serum Choline elevations with significant elevation persisting for as long as 12 hours.

Most orally-ingested supplemental Phosphatidylcholine is utilized by the Liver (usually for Liver repair). Very little Phosphatidylcholine reaches the blood stream, other tissues and other organs of the body. This can limit the effectiveness of oral Phosphatidylcholine. Intravenous administration of Phosphatidylcholine circumvents this Liver domination of Phosphatidylcholine

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A Closer Look at the Working of Antioxidants in Cancer Patients

A Closer Look at the Working of Antioxidants in Cancer Patients

Antioxidants are always debated as to their merits in the treatment of cancer patients. Especially when people are on chemotherapy this question is often asked, so let’s have a closer look at the working of antioxidants and also their merits and exceptions for use.

Antioxidants Anticancer Mechanisms:

  1. Antioxidants inhibit protein kinase c, restraining tumour cell division and proliferation
  2. Antioxidants inhibit oncogene expression, genes that give rise to tumours
  3. Antioxidants promote differentiation by altering growth factors. Undifferentiated cells depart (in appearance) from the highly recognizable (differentiated) cells of the tissue of origin
  4. Antioxidants block destruction imposed by free radicals, protecting vital tissue from damage

Exceptions & Contraindications for the use of Antioxidants

Three agents, classified as antioxidants, have been shown to decrease the effectiveness of radiation or chemotherapy in vivo (1) :

  1. N-acetyl cysteine (NAC) reduced the therapeutic effect of anthracycline –type chemotherapy agents (doxorubicin and bleomycin), which kill cells by generating oxygen radicals. Alkylating agents (such as cisplatin) and hormonal therapies were not affected
  2. Beta-carotene decreased the effectiveness of antimetabolites (5-fluoruracil and methotrexate). Conversely, beta carotene increased the efficacy of radiotherapy, as well as alkylating agents, anthracycline, and platinum chemotherapy agents
  3. Tangeretin (a flavanoid found in citrus fruit) reduced the chemotherapeutic effect of platinum compounds such as cisplatin and carboplatin. Tangeretin interfered with tamoxifen, a nonsteroidal antiestrogen used to treat estrogen-dependent cancers.

High Dose Antioxidants
During Chemotherapy
& Radiation

Studies have demonstrated that antioxidant vitamins can enhance the efficacy of certain chemotherapeutic agents on tumor cells in culture (2). Antioxidant vitamins could be an important adjuvant to standard treatment of human cancers (3)

An in vivo study : antioxidant vitamins could enhance the cytotoxic and apoptotic effects of paclitaxel and carboplatin on non-small cell lung cancer. (4)  The human non-small cell lung cancer cell line H-520 was treated with a mixture of the antioxidant vitamins c,e, and beta carotene and paclitaxel and carboplatin, both individually and in combination of various doses in different sequences.

The apoptosis achieved was as follows :

  • antioxidant vitamins : 15%
  • paclitaxel and carboplatin 40%
  • paclitaxel treatment 24 hours prior to carboplatin treatment caused 54% apoptosis
  • cells pretreated with an antioxidant vitamin mixture immediately before treatment with paclitaxel and carboplatin 70% apoptosis
  •  pretreated with the antioxidant mixture 24hrs prior to treatment with paclitaxel, then followed 24hrs later by treatment with carboplatin 89% apoptosis

Some leaders in the field endorse pulse therapy as the appropriate means of administering nutritional support concurrent with toxic treatments.    Re-entering the supplementation 2-3 days after the large chemotherapeutic bolus allows time for a massive cancer kill followed by a period of rebuilding (5).     If using conventional treatment, this dosing allows the body the full effects of conventional treatments, plus the benefit of an antioxidant program a few days later.

Another study on advanced colorectal cancer (6) using 12 patients using 750mg vit e 2 weeks prior to chemotherapy and radiation showed that short term supplementation increased cd4:cd8, enhanced T-cell to produce T helper 1 cytokines, interleukin 2 and interferon gamma.Dietary vit e may be used to improve the immune functions in patients with advanced cancer.

Another systematic review (7) evaluated the efficacy of CoQ10 for improved tolerability of cancer treatments. The results suggested that coq10 provides some protection against cardiotoxicity or liver toxicity during cancer treatement.

A landmark paper by block (8) on the use of antioxidants and cancer chemotherapy published in 2007 is summarized as follows :

  • 19 trials, randomized, concurrent with chemotherapy
  • survival or response was reported
  • glutathione, melatonin, vit A, Vit C, Vit e, NAC, egalilic, Mix were used
  • none reported decrease in efficacy of chemotherapy
  • many reported :
    • increased survival time
    • tumor response
    • fewer toxicities

The Chemotherapeutic
Effects of High Dose
Intravenous Vit C :

  1. Remember at high doses, iv vit c is a pro-oxidant not an antioxidant
  2. Immune system enhancement
  3. H2O2 (hydrogen peroxide) production, most tumor cells are catalase deficient and cannot metabolize this (9)
  4. Apoptosis (increase in p53, p21, cellular Ca, and a decrease in mitochondrial membrane potential and activation of caspase 3. (10)
  5. Hypoxia Inducible Factor (11)
  6. Anti-angiogenic effect (12)
  7. Generation of 3-mercapto propionaldehyde (13)
  8. Other possible mechanisms : reduction of igf1 (14), inhibition of cox2 (15), intracellular red-ox-signal transduction-gene expression, collagen-extracellular matrix encapsulation (16)
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References :

  1. Bracke et al. 1999
  2. Prasad KD. Integr cancer Ther. 2004; 3:310-22
  3. Prasad et al , 1999
  4. Pathak et al.   J Am Coll Nutr. 2002;21:416-21
  5. Bland 1999;2001
  6. Malmberg KJ. Et al. Clin Cancer Res. 2002; 8:1772-8
  7. Roffe l, et al J Clin Oncol. 2004;22:4418-24
  8. Block et al.    Cancer Treatment Reviews. 2007; 33:407-418
  9. Chen Q et al PNSA. 2005; 102:13604-9
  10. Melanoma Res. 2006 Dec;1696):509-19
  11. Gao P et al.   Cancer Cell 2007; 12:230-8
  12. Mikirova N. et al J Transl Med. 2008; 6:50
  13. Toohey Jl.    Cancer Letters. 2008; 263:164-9
  14. Lee SK et al. J Cell Physiol 2008;216:180-8
  15. Catani MV et al.    Biochem J 2002; 364;441-7
  16. Cameron E. etal.   Int J Vitamin Nutr res; 1982:115-27

Vitamin D – Are You Getting Enough?

Are You Getting Enough Vitamin D ?

The majority of people are deficient in vitamin D. The reasons for this include the use of sunscreens, spending more time indoors, and less efficient absorption of vitamin D as we age. Darker skin and living at higher latitudes also increases the risk. People at extreme risk include house or office bound people, those with renal disease, persistent musculoskeletal pain; osteoporotic people, inflammatory bowel dis- ease or celiac disease and people who are on anticonvulsants. The best measure of vitamin D levels is 25 hydroxy vitamin D. Deficiency is less than 20 ng/ml, normal levels are above 32 ng/ml, but optimal levels are in the range of 60 ng/ml. The old dose recommendation of 400 IU/day of vitamin D is not sufficient to prevent fractures in the elderly. Doses of above 1000 IU (especially if older than 50) are required to prevent deficiency. Doses of up to 2000 IU have been proven safe. (1)

Vitamin D is important for calcium absorption, immunity, avoidance of autoimmune reactions, mainte- nance of weight and blood pressure, prevention of arterial calcifications and also for the prevention of cancer.

Michael Holick of Boston University says “sensible sun exposure (usu- ally 5-10 minutes of exposure of the arms and legs or the hands, arms, and face, 2 or 3 times per week) and increased dietary and supplemental vitamin D intakes are reasonable approaches to guaran- tee vitamin D sufficiency.” (2)

Robert Heaney of Creighton University claims that it would require 2600 international units of

Oral vitamin D3 to ensure that 97.5% of older women achieve optimal

vitamin D levels.Sunscreen lotions block the vitamin

D producing UV-B rays and allows the deeper penetrating UV-A rays to reach the skin. Mortality rates due to malignant melanoma increased after the initiation of campaigns to promote the use of sunscreen lotion blockers in the 1970s. It is important for the skin to be exposed to UV-B sun rays, which help in the production of vitamin D naturally. Sunscreen lotions applied to the face though will protect from premature wrinkling. Safer ways to protect the skin from sun damage and skin cancer includetopical or oral anti- oxidant supplements. For example topical vitamin C and E combined with green tea extract, ferulic acid or other antioxidants may be an op- tion to prevent skin aging and skin cancer. (4)

Here are some of the
health benefits of
Vitamin D

Higher vitamin D levels have been associated with a lower risk of dying from all causes over a 7 year period, as well as specifically from cardio- vascular disease. (5)

“This prospective cohort study demonstrates for the first time, to our knowledge, that low 25- hydroxyvitamin D and 1.25-dihydroxy vitamin D levels are associated with increased risk in all-cause mortality compared with patients with higher vitamin D levels”

Vitamin D has been linked to the prevention of breast cancer. (6)

The conclusion of this pooled analysis of vitamin D and the prevention of breast cancer was that the intake of 2000 IU/d of vitamin D3, and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in the incidence of breast cancer, according to observational studies.

For women already diagnosed with breast cancer, vitamin D may slow the progression of the disease. In 2006, researchers at the Imperial College of London.(7) Vitamin D levels were significantly higher in the women with early-stage disease than in women whose breast cancer had progressed to a more advanced stage.

In August 2007 researchers at the University of California reported that an estimated 250 000 cancers of the colon and 350 000 breast cancer cases could be prevented worldwide each year with vitamin D supplementation. They recommended doses of 2000 IU/d for a meaningful reduction in breast cancer.(8)

Studies show more
links between
vitamin D &

Multiple Sclerosis. (9)

Children later diagnosed with multiple sclerosis had far lower levels of vitamin D than other youngsters, Canadian researchers reported in studies showing more links be- tween low vitamin D and disease. Other studies show that adults who live in northern latitudes, who get less sun exposure, may have a higher risk of multiple sclerosis. They also support a growing body of studies that link low vitamin D with disease, including breast and colon cancer, heart disease, diabetes and tuberculosis.

Evidence suggests that vitamin D helps lower blood pressure, reduces inflammation and boosts the immune system. Vitamin D acts as an immune modulator. In multiple sclerosis, there are many lines of evidence that immune cells are not regulated properly, and one of the things that influences that balance is vitamin D. Interestingly, Canadians have one of the highest rates of multiple sclerosis in the world. In Canada for 6 months of the year the sun is not intense enough to manufacture vita- min D in the skin.

Low levels of vitamin D are also linked to cardiovascular challenges. (10)

There is an increased incidence of peripheral arterial disease in individuals who have low vitamin D, a new study has found. After examining the data, the study authors found that there was a greater prevalence of peripheral arterial disease in subjects with the lowest levels of vita- min D compared to subjects with the highest levels. For each 10 ng/ml decrease in vitamin D level, the risk for peripheral arterial disease increased by 29 percent.

Vitamin D Could Anti-Age You! (11)

New evidence suggests that high levels of vitamin D has a strong correlation with increased leukocyte telomere length. This is important for one’s health and longevity. Leukocytes (white blood cells) are the backbone of the body’s immune system. Like all cells, leukocytes contain our chromosomes, which consist of dna and associated proteins. Telomeres are tiny terminal segments at each end of the dna molecule. They serve a vital role by protecting dna from damage during cell division.

Telomeres also prevent the ends of dna molecules from joining to each other to form loops, or from joining end-to end with the dna in other chromosomes-disastrous scenarios both. By extending the length of the dna strands with their genetically blank material, they give the enzymes enough space to work with in replicating the genetically useful material all the way to its end, thus preserving every last gene. Were it not for this protective action, some of that material would be lost in each replication, resulting in deterioration of cell function, and of one’s health.

Telomere length decreases in cells as we age, ultimately resulting in aging of the cell, and eventually no further cell division. A ribonucleo protein telomerase, whose function is to extend the length of telomeres is only found in appreciable amounts in sex cells, stem cells and UNFORTUNATELY cancer cells. Extending telomere length has huge potential as an anti-aging tool in preserving the cellular and dna health.

PhytoMulti – Boosts Health,
Recharges, Nourishes And
Defends Cells

Now Available
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Vitamin D and diabetes

Recent research has demonstrated that those who receive high amounts of vitamin D during childhood have a lower risk of developing type 1 diabetes later on in life, the greater the amount of vitamin D, the great- er the benefit. (12)

Type 1 diabetes comes about due to the insulin producing beta cells of the pancreas being destroyed by our own immune system, starting early in childhood.

Vitamin D and brain function

Because of the vitamin D receptors in the brain, it has been discovered that vitamin D plays a very important role in maintaining and achieving a healthy mind. What is known also is that low vitamin D levels have been implicated to increase depression in the elderly. This information is useful because depression can potentially be treated in the future with vitamin D rather than with dangerous psychotropic medications. (12)

Vitamin D – a new pain killer?

Women who get the right amount of vitamin D are less likely to suffer from chronic widespread pain, according to a new study in the annals of rheumatic diseases. Vitamin D is actually a hormone that is intimately involved with bone and immune system health. In addition to promoting normal bone development, there is evidence (as outlined above), that getting enough vita- min D helps protect against multiple sclerosis, type 1 diabetes, and certain cancers. Studies have shown that many people suffering from chronic pain have low vitamin D levels and that supplementing with vitamin D can relieve certain types of pain. (13)

Good food sources of vitamin D include:

Egg yolks, fortified foods, and oily fish such as salmon and her- ring. For most people supplementing though with 1000-2000 IU is the way to go. Suggested is to check your levels. Personally I am finding in my practice that more than 70% of my clients are deficient in vitamin D and require supplementation. It is my belief that this critical vitamin can no longer be overlooked or underestimated!

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NAD+ Has Anti-Aging Effects, Boost Energy & Metabolism

NAD+ Has Anti-Aging Effects, Boost Energy & Metabolism

ANTI-AGING

Although we naturally produce NAD+ it, like most things, it reduces with age. This amazing molecule is mostly regarded for its effect on aging and is considered the closest we’ve gotten to a fountain of youth. Intravenous use of NAD+ activates enzymes in the bloodstream called sirtuins which promotes the good aspects of your genes which facilitates one to stay healthier for longer, reducing the side effects of aging.

NAD+ Treatment Protocol: 2 Hour Infusion of 250mg NAD+

Intravenous NAD+ Therapy
&
Neurodegenerative Diseases

With intravenous NAD+ therapy, the molecule works rapidly to repair cells throughout the body and neurons in the brain. It serves as a catalyst in ultimate brain renovation, allowing us to mentally reach higher than ever before and helps overcome depression, anxiety and common mood disorders. With optimal brain function, you can make everyday a good day.

NAD+ Treatment Protocol: 4 Hour Infusion of 500mg NAD+

Opiate & Alcohol
Detox

NAD+ has been linked to brain renovation and drastically reduces drug dependence by rejuvenating the opiate receptors. Restoration of proper brain biochemistry helps to break addiction. Replenish brain nutrients that have been depleted by substance abuse.

NAD+ Treatment Protocol:
8 Hour Infusion of 1000mg NAD+
6 Hour Infusion of 750mg NAD+
4 Hour Infusion of 500mg NAD+

BENEFITS OF NAD INFUSIONS

  • Increased metabolism.
  • Increased energy.
  • Pain alleviation.
  • Reduced inflammation.
  • Alleviate opiate or substance withdrawal symptoms.
  • Prevent and correct DNA damage.
  • Increased anti-aging benefits.

SIDE EFFECTS

Due to extra ATP, which is fuel for your cells throughout your body, NAD+ treatment must be infused over 2 hours minimum or it can cause increase in physiological activity including but not limited to:

  • Chest pressure.
  • Increased energy.
  • Increased muscle excitability.
  • Reduced inflammation.
  • Intestinal cramps.
  • Light headedness.
  • Nausea.
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NAD INFUSIONS
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Improve Concentration & Memory with Phosphatidylserine

Improve Concentration & Memory with Phosphatidylserine

Phosphatidylserine, or PS for short, belongs to a special category for fat-soluble substances called phospholipids. It is a natural compound that is found in the membranes of all the body’s cells, where it is essential for normal functioning. PS is especially highly concentrated in brain cells, where it helps regulate neurotransmitters, the chemical messengers that carry nerve impulses to and from the brain.

Role as a supplement :

PS may be helpful in supporting mental function. Studies indicate that taking supplemental PS may improve concentration and memory in people suffering from age-related memory loss, dementia, and Alzheimer’s disease

Evidence of efficacy :

Most of the research with PS has been done in Europe, where researchers report that taking 300mg a day can significantly improve memory and cognitive function (the ability to think, reason, and concentrate) among people who have suffered a decline in their normal mental abilities.    The best results have been found when people were given PS in the early stages of dementia and Alzheimer’s disease. Although mental-function tests show significant improvements in Alzheimer’s patients, researchers caution that it’s generally not enough to make a real difference in the ability to function on a day-to-day basis.

In one study of
51 subjects over 71 years of
age, those given PS for 12
weeks showed improvements in…

Less research has been done on the benefit of PS among people suffering from normal age-related memory loss, but it is thought to be helpful. PS has not, however, been shown to improve a young, healthy person’s ability to think or remember facts. In contrast, older people seem to benefit from the supplements. In one study of 51 subjects over 71 years of age, those given PS for 12 weeks showed improvements in their abilities to maintain concentration and to recall names of familiar people, the location of misplaced objects, and details from the previous day and past week, and also improvements in their ability to concentrate. Follow-up studies showed that the benefits may last for several months after PS supplementation stops.

Sources :

Originally PS was extracted fromcattle brains, but the scare over mad cow disease had researchers  scrambling for a new source.     PS now comes from soy, which is a natural rich source.      At least one study found PS from soy to be just as effective as that extracted from cow’s brains.
PS is found in only trace amounts in a typical diet, with lecithin providing very small amounts.     However the body manufactures what it needs from phospholipid building blocks.

Forms and usual dosage :

PS is available in capsule form and as a chewing gum.    The recommended dosage is 300mg a day, divided into three doses, for 3-4 weeks.     Once improvement is noted, a maintenance dose of 100mg/day is recommended.    Capsules typically provide 100mg each, whereas 2 pieces of gum provide about 85mg/d

Added benefit of PS :

It lowers cortisol and helps with adrenal hormone balance!

Potential problems :

No side effects associated with PS have been reported, although one expert has suggested that taking PS at night may affect sleep.

Look for PS derived from soy in capsule form.    It takes at least 6 or more pieces of gum a day to deliver the amount of PS found in 3 capsuls of 100mg

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