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Cytokines are powerful communication molecules capable of regulating a wide spectrum of biological functions, including a crucial role in the immuno-pathogenesis of disease. Two general constellations of cytokines are associated with functional immune responses. These are classified as either TH1 or TH2 and can be distinctly observed during disease.
IL-2
Interleukin-2
Inflammation
IL-12
Interleukin-12
Autoimmune diseases (RA, MS, IDDM), tumor, Graft vs. Host Disease, Infections, HIV, Glomerulonephritis
IFN-γ
Interferon-γ
Inflammatory diseases (infection, Dermatitis), autoimmune diseases (RA, MS, IDDM, SLE), tumors, Hepatitis B and C
TNF-α
Tumor necrosis factor-α
Inflammatory diseases, autoimmune diseases (RA, IDDM, MS, CD), Psoriasis, chronic Hepatitis B and C, SLE, tumors, chronic lymphatic Leukemia, Schizophrenia
IL-4
Interleukin-4
Asthma, Allergy, Malaria, Hepatitis C
IL-5
Interleukin-5
Asthma, Allergy
IL-6
Interleukin-6
Inflammatory diseases (viral and bacterial infection), autoimmune disease (RA, SLE, etc.), Schizophrenia
IL-10
Interleukin-10
Autoimmune disease, IgE-mediated Asthma, Hepatitis B and C, IBD, Septic shock, mostly during recession of diseases
IL-13
Interleukin-13
Asthma, Allergy, COPD
GM-CSF
Granulocyte-macrophage colony- stimulating Factor
Inflammation (bacterial infection, Asthma), autoimmune diseases, toxic shock
IL-17
Interleukin-17
Inflammatory diseases (inflammatory airway diseases), autoimmune diseases (RA, MS, Crohn’s Disease, etc)
IL-1β
Interleukin-β
Inflammatory diseases (Periodontitis, Colitis, IBD), autoimmune diseases (RA, IDDM, MG), Schizophrenia
IL-7
Interleukin-7
Osteolytic Cancer, Lymphopenia, high in untreated advanced HIV patients and in those who fail to respond to HAART therapy
IL-8
Interleukin-8
Autoimmune diseases (RA, Crohn’s disease), Uveitis, Colitis, acute inflammatory diseases
G-CSF
Granulocyte colony stimulating factor
Autoimmune disease, IgE-mediated Asthma, Hepatitis B and C, IBD, Septic shock, mostly during recession of diseases
MCP-1
Monocyte chemoattractant protein-1
Inflammatory diseases (Glomerulonephritis, Allergy), Atherosclerosis, Neoplasm, human immunodeficiency infection, autoimmune diseases (RA, MS), Alzheimer’s disease
MIP-1β
Macrophage inflammatory protein-β
Acute infections such as bacterial Sepsis, Plasmodium, HIV, lung disease- Sarcoidosis, autoimmune diseases (RA, MS), Colitis, Asthma
TGF-1β
Transforming growth factors-β
Inflammation, wound healing, bone formation, fibrotic conditions, carcinogenesis, immunosuppressive disorders, neurodegenerative disease, coronary artery disease, SLE, RA
*This chart is not to be used for diagnostic purposes. This is only for general information on the role cytokines might play in human disease.
Pro-inflammatory cytokines
IL-1β , IL-2, IL-6, IL-8, IL-12, IL-17, IFN- γ, TNF-α
Anti-inflammatory cytokines
IL-4, IL-5, IL-10, IL-13, TGF-β
Chemokines
IL-8, MCP-1, MIP-1β
Reference:
Neurolief.com