Lipoprotein Particle Size

Posted On November 25, 2020 at 11:48 am by / No Comments

Lipoprotein Particle Size

Up to 50% of those who suffered heart attacks had “normal” cholesterol numbers. How can the large discrepancy between accurate diagnosis and standard cholesterol testing be prevented? Simply by testing the LDL particle numbers using the lipoprotein particle profile.

Overview: Cholesterol testing has historically been used as the standard indicator for cardiovascular disease classified as HDL (good) and LDL (bad). However, it is actually the lipoprotein particles that carry the cholesterol throughout the body, not necessarily the cholesterol  within them, that are responsible for key steps in plaque production and the resulting development of cardiovascular disease.

Approximately 50% of people suffering from heart attacks have shown “normal” cholesterol numbers (NIH – National heart blood and lung institute)

Now there is an advanced cholesterol testing technology which accurately measures both the density and number of lipoprotein particles. This test is the lipoprotein particle profile.  Measuring the lipoprotein subgroups is the only way to evaluate new risk factors, which is crucial for an accurate assessment of cardiovascular risk – according to the National Cholesterol Education Program (NCEP).

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NCEP new risk factors:

  • Small, dense LDL : these atherogenic particles are easily oxidized and penetrate the arterial endothelium to form plaque
  • RLP (remnant lipoprotein) : is very atherogenic, has a similar composition and density of plaque, is believed to be a building block of plaque and does not need to be oxidized like other ldl particles
  • Lp(a) : this small, dense LDL is involved in thrombosis
  • HDL2b : positively correlates with heart health health because it is an indicator of how well excess lipids are removed
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