Mitochondria And The Energizing Power Of PQQ

Posted On October 9, 2020 at 12:26 pm by / No Comments

Mitochondria And The Energizing Power Of PQQ

Mitochondria have their own DNA, so they can multiply independently of cellular division.

PQQ is a nutrient that helps one make new mitochondria.

Of late PQQ has been gaining attention and I quote here from Life extension magazine….

””The latest advance in the area of mitochondrial bioenergetics is the coenzyme pyrroloquinoline quinone or PQQ. PQQ’s critical role across a range of biological functions has only gradually emerged. Like CoQ10, it is a micronutrient whose antioxidant capacity provides extraordinary defense against mitochondrial decay. But the most exciting revelation on PQQ emerged early in 2010, when researchers found it not only protected mitochondria from oxidative damage—it stimulated growth of fresh mitochondria.    Mitochondrial dysfunction has been definitively linked to virtually all killer diseases of aging, from Alzheimer’s disease and type 2 diabetes to heart failure. Researchers have recorded evidence of greater mitochondrial damage in the brain cells of humans over 70 compared to those in their early 40s. Many scientists believe mitochondrial longevity determines overall longevity. A next-generation coenzyme is being introduced called pyrroloquinoline quinone or PQQ that has been shown to induce mitochondrial biogenesis—the growth of new mitochondria in aging cells. While CoQ10 optimizes mitochondrial function, PQQ activates genes that govern mitochondrial reproduction, protection, and repair. PQQ also affords potent cardioprotection and defense against neuronal (brain) degeneration. Published studies show that 20 mg of PQQ plus 300 mg of CoQ10 may reverse age-related cognitive decline in aging humans.””

PGC 1 alpha and genetic control of mitochondrial biogenesis can be influenced by life style and supplementation including :

  • L-arginine, alpha ketoglutarate, whey protein fractions elevate Nitric oxide which stimulates PGC1alpha
  • Resveratrol, quercetin, pterostilbene and exercise stimulate SIRT 1 activity which stimulates PGC1alpha
  • Alpha lipoic acid and biotin (vitamin B7) upregulate AMPK which also upregulates PGC 1 alpha

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PQQ Now Available Online

PQQ’s amazing mitochondrial-boosting abilities have been documented by University of California Davis researchers who are considered pioneers in the study of PQQ.

Science Stands Behind the Energizing Power of PQQ

The Journal of Biological Chemistry reports that nutrients like PQQ “improve energy” by stimulating the creation of new mitochondria.4

With new power generators, your old cells can produce energy like new cells.

In addition, Biochemical Pharmacology 5 reports that PQQ is up to 5,000 times more efficient in sustaining energy production than common antioxidants.

This brain “supercharger” rejuvenates an aging brain.

PQQ improves Brain function in 5 major ways :

  1. PQQ triggers an aging brain to grow new mitochondria, the “power generators” your brain needs for better memory and clearer thinking.
  2. PQQ protects existing mitochondria in your brain cells by mopping up free radicals and reducing oxidative stress, hallmarks of memory loss.
  3. PQQ stimulates the production of nerve growth factor (NGF), which triggers the growth nerve cells in your brain for sharper thinking.8
  4. PQQ reduces the dangerous effect of excitotoxicity in your brain cells. Excitotoxicity is when your brain’s neurons get overstimulated by toxic chemicals or electronic impulses. This overstimulation is linked to many types of age-related memory and cognitive problems.
  5. PQQ protects your brain from memory-robbing plaques.9
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References :

  1. Goepp J. “Reverse mitochondrial damage. Potent molecular energizers for lifelong health.” Life Extension Magazine. February 2010.
  2. Pieczenik SR and Neustadt J. “Mitochondrial dysfunction and molecular pathways of disease.” Exp Mol Pathol. 2007;83(1):84-92.
  3. Stites TE, et al. “Physiological importance of quinoenzymes and the O-quinone family of cofactors.” J Nutr. 2000;130(4):719-727.
  4. Chowanadisai W, et al. “Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1 alpha expression.” J Biol Chem. 2010;285:142-152.
  5. He K., et al. “Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems.” Biochem Pharmacol. 2003;65(1):67-74.
  6. Facecchia K, et al. “Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies.” J Toxicol. 2011;2011:683728.
  7. Nakano M, et al. “Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons (in Japanese).” Food Style 21. 2009;13(7):50-53.
  8. Zhou L and Too HP. “Mitochondrial localized STAT3 is involved in NGF induced neurite outgrowth.” PLoS One. 2011:6(6);e21680.
  9. Zhang JJ, et al. “Protective effect of pyrroloquinoline quinone against Aβ-induced neurotoxicity in human neuroblastoma SH-Sy5Y cells.” Neurosci Lett. 2009;464(3):165-169.
  10. Koikeda T Medical Consultation and New Remedies
  11. Civitarese AE, et al. “Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.” PLoS Med. 2007;4(3):e76.
  12. Nakano M, et al. “Effects of pyrroloquinoline quinone disodium salt intake on the serum cholesterol levels of healthy Japanese adults.” J Nutr Sci Vitaminol (Tokyo). 2015;61(3):233-240.
  13. Wada H, et al. “Redox status of coenzyme Q10 is associated with chronological age.” J Am Geratr Soc. 2007;55(7):1141-1142.
  14. Yan J, et al. “Reduced coenzyme Q10 supplementation decelerates senescense in SAMP1 mice.” Exp Gerontol. 2006;41(2):130-140.
  15. Baggio E, et al. “Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure (interim analysis).” The Clinical Investigator. 1993;71:S145-S149.
  16. Wadsworth TL, et al. “Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer’s disease.” J Alzheimer’s Dis. 2008;14(2):225-234.
  17. Shetty RA, et al. “Coenzyme Q(10) supplementation reverses age-related impairments in spatial learning and lowers protein oxidation.” Age (Dordr). 2013;35(5):1821-1834.
  18. Hodgson JM, et al. “Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes.” Eur J Clin Nutr. 2002;56(11):1137-1142.
  19. Qu J, et al. “Coenzyme Q10 in the human retina.” Invest Opththalmol Vis Sci. 2009;50:1814-1818.
  20. Blasi MA, et al. “Does coenzyme Q10 play a role in opposing oxidative stress in patients with age-related macular degeneration?” Ophthalmologica. 2001;215(1):51-54.
  21. Gazdik F, et al. “Decreased levels of coenzyme Q(10) in patients with bronchial asthma.” Allergy. 2002;57(9):811-814.
  22. Hanioka T, et al. “Effect of topical application of coenzyme Q10 on adult periodontitis.” Mol Aspects Med. 1994;15 Suppl:s241-248.
  23. Folkers K, et al. “Effective treatment with coenzyme Q10 of patients with chronic myocardial disease.” Drugs Exp Clin Res. 1985;11(8):577-579.
  24. Quiles JL, et al. “Coenzyme Q10 supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet.” Exp Gerontol. 2004;39(2):189-194.
  25. Langsjoen PH. “Supplemental ubiquinol in heart patients: five year experience.” 2010.
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