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Photodynamic Therapy (PDT) is one of the most interesting and promising treatment approaches in modern medicine. Up to now it is approved and used very successfully in oncology, dermatology and pathogen inactivation. The principle is the stimulation of a nontoxic light-sensitive substance (photosensitizer) administered intravenously, orally or topically with (laser) light of the corresponding wavelength.
The sensitizer binds with very high specificity to malignant cells or pathological microorganisms like bacteria, viruses and microbes. For example, Vitamin B2 (Riboflavin) is able to bind specifically to the RNA of coronaviruses. The stimulation with light of the respective wavelength leads to the formation of reactive oxygen species (ROS) directly at the site of action which ultimately destroys the targeted cells. One of the major advantages of Photodynamic Therapy is that it can be applied with minimal to no side-effects.
In comparison to surgical lasers (hard lasers), Low-Level Lasers (also called soft or cold laser) utilize low-intensity irradiation to generate regenerative effects instead of damaging tissue.
Through different endogenous chromophores, micro-biological structures can absorb the light energy in form of photons. Thereby, they trigger photophysical and photochemical events at various biological scales which eventually lead to various cellular effects, depending on the wavelength of the light, its power and the exposure time.
An example is the absorption within the mitochondrial respiratory chain that causes a signaling cascade resulting in an increase of cellular energy production (ATP) and a normalization of the membrane potential. Low-Level Laser Therapy is well-proven, has no side-effects and is minimal- to non-invasive and therefore well tolerated.
The world is currently confronted with a type of coronavirus that wasn’t known a year ago. Respiratory viruses enter a person almost exclusively through mouth and nose and SARS-CoV-2, as we know in the meanwhile, usually stays within the respiratory tract. Only a small portion of the viral load reaches the blood stream, which makes a local treatment approach evident. On the other hand, more and more cases reporting of multiple organ dysfunctions raise international interest. They involve e.g. cases of kidney failure, brain dysfunctions or cardiovascular complications like the formation of thrombosis or even heart failure in acute COVID-19 patients.
We therefore believe that the key to effective treatment and prevention against COVID-19 and other diseases caused by respiratory viruses like the flu lies in the combination of an effective local reduction of the viral load and additional systemic inactivation of pathogens present in the blood stream, without harming other body components. The underlying mechanisms of the principle we apply for this are exploited and researched for years already:
The application of riboflavin with subsequent UV irradiation in blood transfusions is already applied in extracorporeal viral inactivation very successfully. For example, in convalescent plasma treatments (transfusion of infected blood to introduce anti-bodies to the body) for Ebola patients this technique reduced the virus titers to below limits of detection and therefore ensures that the treatment doesn’t bear the risk of reinfection (DOI: 10.1111/trf.13393).
In April 2020, Keil et al. could show that the same approach is able to reduce the viral titer of the new SARS-CoV-2 virus beyond the level of detection, concluding that that the process would be effective in reducing the theoretical risk of transfusion transmitted SARS-CoV-2 (DOI: 10.1111/vox.12937).
Through advancements in laser technology, we are nowadays able to conduct these treatments systematically within the body or directly at the affected area as well. For the inactivation of pathogens this method is called antimicrobial Photodynamic Therapy (aPDT) and it effectively and safely fights bacteria, viruses and parasites as the following study demonstrates.
In 2017, Weber / Junggebauer / Ali conducted a study in 20 patients suffering from the severest form Malaria, Plasmodium Falciparum. The patients were equally assigned to a control and a study group, with the control group receiving conventional treatment and the study group receiving a protocol with IV riboflavin and subsequent laser irradiation. The study showed that the aPDT was more effective (89 % tested negative at study end vs. 50 % in control group), reduced number and severity of symptoms and didn’t have adverse effects on the blood components (study not published, click here to download).
The Laser Watch Spectra is an innovative home therapy device, reflecting the latest research findings in the field of Low-Level Laser Therapy. It irradiates the main arteries on the wrist (see picture below) and can also be used for photodynamic home therapy – locally and systemically when combined with a photosensitive substance.
The Watch is equipped with all 4 colors of the visible light spectrum to make use of their distinct therapeutic effects (Red: stimulation of immune activity & improvement of microcirculation, Green: increase of oxygen supply, Blue: release of nitric oxide NO and opening of microvessels, strong anti-inflammatory effect, Yellow: increase of melatonin and serotonin production).
All colors together ideally stimulate the mitochondria present in our cells and provide them with additional energy. This also holds true for the stem cells present in our blood as they possess an extra high number of mitochondria. After stimulation, the proliferation rate and differentiation ability of the stem cells increase and therefore the regeneration of damaged tissue improves.
Different accessories that can be operated simultaneously with the watch enable more specific treatments of certain areas.
CONTINUOUS IMMUNE STIMULATION
Application of Laser Watch at full power, all colors for 1 hour daily.
PREVENTION AGAINST VIRAL OUTBREAK
Application of the Home PDT protocol once a week during increased viral incidence or after contact with infected persons. Applies not only to corona, but also to other respiratory infections and influenza.
MITIGATING COURSE OF ACUTE DISEASE
If you have an acute outbreak of COVID- 19, please consult your doctor and follow the advice. Additionally, daily application of Home PDT protocol can decrease number and severity of symptoms.
For the treatment of children < 10 years reduce treatment time with the watch to 30 mins. A yellowish discoloration of the urine after intake of high doses of Vitamin B2 (Riboflavin) is natural and will disappear again after stopping the intake.