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As part of the blood tests we recommend as part of the Bredesen Protocols we also advise that participants determine if they are positive for the ApoE4 gene. Being positive for ApoE4 is the most common genetic risk for dementia.
Every person should therefor get tested for the ApoE4 gene especially if you have dementia in your family to know what your vulnerability for dementia is.
75% of people do not have this gene – Their risk to get dementia is about 9%.
25% of people have this gene – If they have one copy of the gene their risk to get dementia is about 30%.
About 2% of people have two copies of the ApoE4 gene and their risk to get Alzheimer’s is about 50%
We want to educate you regarding the impact of ApoE4 for you to make an informed decision as to whether you want to test for ApoE4 so that if you test positive you know what it means for you.
If you test positive, please remember this:
This means that you can influence how your genes will be expressed and determine your life. If you live a healthy life your gene pre-disposition will not affect you negatively, but the reverse is also true.
So, the choice is yours especially if you test positive for ApoE4. At least you then know what your vulnerability is.
ApoE4 carriers living an unhealthy lifestyle may be prone to:
IF you test positive, please take the follow remedial action you can consider reducing your risk for dementia. All of this is part of the Bredesen PreCODE and ReCODE protocols.
Hyper absorb fat leading to elevated cholesterol
Increased blood-brain permeability – higher exposure to gluten and toxins
Demonstrating an asymptomatic mild reduction in glucose utilization as early as age 20 – monitor symptoms of insulin resistance and consider low ketone levels from this age to help.
Reduced synaptic plasticity also called neuroplasticity which is the ability to change brain structures
Inhibiting neurogenesis and reduce the formulation of BDNF – brain cell growth factors needed by the brain to function well.
Negative impact on vascular function
Impaired mitochondrial function and increased oxidative stress
Inhibited toxin clearance
Inhibited amyloid clearance
Inhibited nutrient transportation
ApoE4 carriers respond successfully in preventing and reversing cognitive decline by following the Bredesen Protocols
The benefit of knowing your ApoE4 status is that you can decide to take your brain serious and care for it by following the Bredesen Recode Protocol.
If you test positive for ApoE4 you know that you must make a serious effort to live healthy and decrease all the risk factors. Even if you did not test positive for it, you should still do this.
To care for your brain should be a No-brainer.