Phosphocomplex® Liver Protection – Now Available At Dr Golding’s Medical Practice

Several studies have also demonstrated that Silybin stimulates synthesis and activity of enzymes responsible for detoxification pathways in liver and also blocks the oxidative toxicities of alcohol, carbon tetrachloride and mushroom toxins. Silybin is poorly absorbed by the intestine, that limits its benefits because of :

• Multiple-ring large size molecules which cannot be absorbed by simple diffusion
• Poor miscibility with lipids, severely limiting their ability to pass across the lipid-rich outer membranes of the enterocytes of the small intestine
• Extensive phase II metabolism and rapid excretion in bile and urine, The poor water solubility and bioavailability of silybin have inspired to the development of enhanced formulations to increase its absorption. A complex of silybin and phospholipids has shown to be about 10 times more bioavailable than silybin itself (Kidd P. et al., Alternative Medicine Review: a Journal of Clinical Therapeutic 10 (3): 193–203,2005.

Biological & Functional Roles In A Healthy Liver

Phosphatidylcholine focus:

Phosphatidylcholine (PC) has also biological and functional roles in healthy liver. It is one of the most important support nutrients for the liver, a large biological molecule that is a universal building block for cell membranes. More than 2 decades of clinical trials indicate that PC protects the liver against damage from alcoholism, pharmaceuticals, pollutant substances, viruses, and other toxic influences, most of which operate by damaging cell membranes. Dietary supplementation with PC (a minimum 800 mg daily, with meals) significantly speeds recovery of the liver. PC is fully compatible with pharmaceuticals, and with other nutrients. PC is also highly bioavailable (about 90% of the administered amount is absorbed over 24 hours), and PC is an excellent emulsifier that enhances the bioavailability of nutrients with which it is coadministered. (Kidd PM. Phosphatidylcholine: A Superior Protectant Against Liver Damage. Alternative Med. Rev. 1996) PC’s diverse benefits and proven safety indicate that it is a premier liver nutrient:

• It is the principal molecular building block for circulating lipoproteins
• It is an important emulsifier in the lungs gastrointestinal tract bile
• It manages the vast majority of life processes
• It acts as a carrier for both fat-miscible and water-miscible nutrient

Uses and doses :

Phosphocomplex® is obtained by hydrogen bonds between the polar head of phospholipids and the polar groups of pure Silybin (≥ 95%). The standardized starting material is equal to ≥29% to ≤37% of Silybin by HPLC. The enhanced absorption through gastro-intestinal tract and the increased bioavailability facilitates liver targeting, with a synergistic effect of the phosphatidylcholine phospholipid as hepatoprotector. Supported by pharmacological and clinical data. Phosphocomplex ™ is a yellow-brownish powder suitable for different formulation such as tablets, capsules and sachets.

At the recommended dosage of 80 – 160 mg/day it may be indicated as a complement product for :

• Fatty Liver –Steatosis
• Alcoholic liver disease
• Also Non Alcoholic Fatty Liver Disease
• Chronic liver disease
• Acute viral hepatitis.

Mechanisms of working of phosphocomplex :

1. Hepatocye protection : promotes hepatocyte protein synthesis, a mechanism forliver cell regeneration

2. Anti-inflammatory effects
a) mastocytes stimulated
b) neutrophil stimulation
c) leucotrine inhibition
d) Prostaglandin, lipoprotein and lnterleucin inhibition

3. Detoxification : increases GSH, increases superoxide dismutase

4. Liver protection : stimulates the flow of bile acid and the production of bile salts, and protection of hepatic tissue.