Quatrefolic The 4th Generation Folate

Posted On July 8, 2020 at 7:07 am by / No Comments

Quatrefolic The 4th Generation Folate

Folate plays an essential role in cell division and DNA synthesis and is involved in human growth and development. Humans need to maintain an adequate dietary intake of folate during various stages of their lives.

Folates contained in foods are unstable and susceptible to oxidation and they lose activity during food processing, manufacturing and storage.

Bioavailability range of 25-50%, depending on the kind of food, Room temperature storage may lose up to 70% of their folate activity within three days, Cooking process in water can increase the loss to 95%.

Primary Folates :

Structurally-related compounds (as polyglutamated forms)

Naturally found in foods

Must be hydrolyzed Unstable (food processing and storage)

Secondary Folic :

Synthetic oxidized form of folate

First synthetized in 1945

More stable than natural form of folate

No active – Needs to be metabolized

Added in supplements and fortified foods

Tertiary Folate (3°) (6S)-5-MTHF   :

The concentration of 5-MTHF in cord serum is approximately 2 times higher than in maternal serum (mean 35.8 vs. 15.6 nmol/L), suggesting that 5-MTHF during pregnancy can provide an immediate source of folate to be transported to the fetus

(6S)-5-MTHF is the main folate form in cord blood (means 89.4% of total folate)

The folic acid that is found most commonly in vitamin supplements and fortified food is NOT folate.

It must be converted from folic acid to methyltetrahydrofolate (5-MTHF) before it can be used by the body.

The big variations in how efficiently folic acid reaches the target organs depend from 2 different points:

1. Gut absorption

2. Liver conversion of FA in the active form

Unmetabolized Folic Acid (UMFA) may be found in the circulation at doses of supplementation of FA > 200μg in normal subjects.

The human gut appears to have a very efficient capacity to convert reduced dietary folates to 5-MTHF but limited ability to reduce folic acid.

Methyltetrahydrofolate Reductase(MTHFR) :

Rate-limiting enzyme that catalyzes the irreversible conversion to 5-MTHF in the methyl cycle

10% of the world’s population is affected by homozygous (TT) MTHFR polymorphism

Particularly common in some ethnic groups, northern China (20%), southern Italy (26%), and Mexico (32%)

Most common uses of folate / Quatrefolic® Folates application areas :

Neural-tube Defects Irritable bowel disease

Male and female infertility Cognitive impairment in elderly

Spontaneous abortion

Lifestyle putting people at risk of low folate levels:



excess Eating disorders

Low vegetables intake

Chronic dieting

Coronary heart disease


Macrocytic anemia


Elevated homocysteine levels



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